Effects of non-invasive brain stimulation on associative memory

Matzen, Laura E.; Trumbo, Michael C.; Leach, Ryan C.; Leshikar, Eric D.

doi:10.1016/j.brainres.2015.07.036

Title: Effects of non-invasive brain stimulation on associative memory

Journal Article · Thu Jul 30 00:00:00 EDT 2015 · Brain Research

DOI:https://doi.org/10.1016/j.brainres.2015.07.036· OSTI ID:1339280

Matzen, Laura E. ^[1]; Trumbo, Michael C. ^[2]; Leach, Ryan C. ^[3]; Leshikar, Eric D. ^[3]

Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)'
Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)'; Univ. of New Mexico, Albuquerque, NM (United States)
Univ. of Illinois, Chicago, IL (United States)

Associative memory refers to remembering the association between two items, such as a face and a name. It is a crucial part of daily life, but it is also one of the first aspects of memory performance that is impacted by aging and by Alzheimer’s disease. Evidence suggests that transcranial direct current stimulation (tDCS) can improve memory performance, but few tDCS studies have investigated its impact on associative memory. In addition, no prior study of the effects of tDCS on memory performance has systematically evaluated the impact of tDCS on different types of memory assessments, such as recognition and recall tests. In this study, we measured the effects of tDCS on associative memory performance in healthy adults, using both recognition and recall tests. Participants studied face-name pairs while receiving either active (30 minutes, 2 mA) or sham (30 minutes, 0.1 mA) stimulation with the anode placed at F9 and the cathode placed on the contralateral upper arm. Participants in the active stimulation group performed significantly better on the recall test than participants in the sham group, recalling 50% more names, on average, and making fewer recall errors. However, the two groups did not differ significantly in terms of their performance on the recognition memory test. This investigation provides evidence that stimulation at the time of study improves associative memory encoding, but that this memory benefit is evident only under certain retrieval conditions.

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Research Organization:: Sandia National Lab. (SNL-NM), Albuquerque, NM (United States)

Sponsoring Organization:: USDOE National Nuclear Security Administration (NNSA)

Grant/Contract Number:: AC04-94AL85000

OSTI ID:: 1339280

Alternate ID(s):: OSTI ID: 1246660

Report Number(s):: SAND-2017-0115J; PII: S000689931500579X

Journal Information:: Brain Research, Vol. 1624; ISSN 0006-8993

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 44 works

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Differential Age Effects of Transcranial Direct Current Stimulation on Associative Memory Leach, Ryan C.; McCurdy, Matthew P.; Trumbo, Michael C. The Journals of Gerontology: Series B, Vol. 74, Issue 7 https://doi.org/10.1093/geronb/gby003	journal	February 2018
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tDCS over the prefrontal cortex alters objective but not subjective encoding Gaynor, Alexandra M.; Chua, Elizabeth F. Cognitive Neuroscience, Vol. 8, Issue 3 https://doi.org/10.1080/17588928.2016.1213713	journal	August 2016
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Theta band high definition transcranial alternating current stimulation, but not transcranial direct current stimulation, improves associative memory performance Lang, Stefan; Gan, Liu Shi; Alrazi, Tazrina Scientific Reports, Vol. 9, Issue 1 https://doi.org/10.1038/s41598-019-44680-8	journal	June 2019

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