skip to main content
OSTI.GOV title logo U.S. Department of Energy
Office of Scientific and Technical Information

Title: Method of assessing heterogeneity in images

Patent ·
OSTI ID:1303430

A method of assessing heterogeneity in images is disclosed. 3D images of an object are acquired. The acquired images may be filtered and masked. Iterative decomposition is performed on the masked images to obtain image subdivisions that are relatively homogeneous. Comparative analysis, such as variogram analysis or correlogram analysis, is performed of the decomposed images to determine spatial relationships between regions of the images that are relatively homogeneous.

Research Organization:
Pacific Northwest National Laboratory (PNNL), Richland, WA (United States)
Sponsoring Organization:
USDOE
DOE Contract Number:
AC05-76RL01830
Assignee:
BATTELLE MEMORIAL INSTITUTE (Richland, WA)
Patent Number(s):
9,424,639
Application Number:
14/166,601
OSTI ID:
1303430
Resource Relation:
Patent File Date: 2014 Jan 28
Country of Publication:
United States
Language:
English

References (40)

Quantitative Computed Tomography in COPD: Possibilities and Limitations journal December 2011
Imaging for lung physiology: What do we wish we could measure? journal July 2012
Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease: NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary journal April 2001
Usefulness of GOLD classification of COPD severity journal September 2003
How much do GOLD stages reflect CT abnormalities in COPD patients? journal July 2008
CT of pulmonary emphysema - current status, challenges, and future directions journal September 2008
Reproducibility of volume and densitometric measures of emphysema on repeat computed tomography with an interval of 1 week journal October 2011
Quantification of Pulmonary Emphysema from Lung Computed Tomography Images journal July 1997
Image reconstruction affects computer tomographic assessment of lung hyperinflation journal June 2008
The Effects of Radiation Dose and CT Manufacturer on Measurements of Lung Densitometry journal August 2007
Automated classification of normal and pathologic pulmonary tissue by topological texture features extracted from multi-detector CT in 3D journal July 2008
MDCT-based 3-D texture classification of emphysema and early smoking related lung pathologies journal April 2006
Interobserver Variability in the Determination of Upper Lobe-Predominant Emphysema journal February 2007
Early Emphysematous Changes in Asymptomatic Smokers: Detection with 3 He MR Imaging journal June 2006
In Vivo Detection of Acinar Microstructural Changes in Early Emphysema with 3 He Lung Morphometry journal September 2011
Heterogeneity of pulmonary perfusion as a mechanistic image-based phenotype in emphysema susceptible smokers journal April 2010
Spatial Heterogeneity of Lung Perfusion Assessed with 13N PET as a Vascular Biomarker in Chronic Obstructive Pulmonary Disease journal December 2009
Spatial and temporal heterogeneity of regional lung ventilation determined by electrical impedance tomography during pulmonary function testing journal October 2012
Fractal feature analysis and classification in medical imaging journal June 1989
Fractal analysis of interstitial lung abnormalities in chest radiography. journal November 1995
Fractal analysis of high-resolution CT images as a tool for quantification of lung diseases conference May 1995
Quantifying tissue heterogeneity using quadtree decomposition
  • Subramaniam, K.; Hoffman, E. A.; Tawhai, M. H.
  • 2012 34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society (EMBC), 2012 Annual International Conference of the IEEE Engineering in Medicine and Biology Society https://doi.org/10.1109/EMBC.2012.6346863
conference August 2012
Region Quad-Tree Decomposition Based Edge Detection for Medical Images journal May 2010
Investigation of the spatial correlation in human white matter and the influence of age using 3-dimensional variography applied to MP-RAGE data journal November 2012
3D 3 He diffusion MRI as a local in vivo morphometric tool to evaluate emphysematous rat lungs journal October 2008
Stable Small Animal Ventilation for Dynamic Lung Imaging to Support Computational Fluid Dynamics Models journal November 2011
Comparative Computational Modeling of Airflows and Vapor Dosimetry in the Respiratory Tracts of Rat, Monkey, and Human journal May 2012
Phase-contrast MRI and CFD modeling of apparent 3He gas flow in rat pulmonary airways journal August 2012
An Official Research Policy Statement of the American Thoracic Society/European Respiratory Society: Standards for Quantitative Assessment of Lung Structure journal February 2010
Comparison of Two Quantitative Methods of Discerning Airspace Enlargement in Smoke-Exposed Mice journal August 2009
Proton and hyperpolarized helium magnetic resonance imaging of radiation-induced lung injury in rats journal April 2004
Changes in Expression of Injury After Irradiation of Increasing Volumes in Rat Lung journal April 2007
Loco-regional differences in pulmonary function and density after partial rat lung irradiation journal October 2003
Comparison of three rat strains for development of radiation-induced lung injury after hemithoracic irradiation journal March 2001
Structural and functional alterations in the rat lung following whole thoracic irradiation with moderate doses: Injury and recovery journal January 2008
Rat model of lung fibrosis: comparison of functional, biochemical, and histopathological changes 4 months after single irradiation of the right hemithorax journal March 2001
Partial volume rat lung irradiation: Temporal fluctuations of in-field and out-of-field DNA damage and inflammatory cytokines following irradiation journal January 2005
CT attenuation of paired HRCT scans obtained at full inspiratory/expiratory position: comparison with pulmonary function tests journal November 2002
Automatic three-dimensional mesh generation by the finite octree technique journal September 1991
Automated measurement of heterogeneity in CT images of healthy and diseased rat lungs using variogram analysis of an octree decomposition journal January 2014