Reactor production of Thorium-229

Boll, Rose Ann; Murphy, Karen E.; Denton, David L.; Garland, Marc A.; Mirzadeh, Saed; Hogle, Susan; Owens, Allison

doi:10.1016/j.apradiso.2016.05.002

Title: Reactor production of Thorium-229

Journal Article · Tue May 03 00:00:00 EDT 2016 · Applied Radiation and Isotopes

DOI:https://doi.org/10.1016/j.apradiso.2016.05.002· OSTI ID:1253240

Boll, Rose Ann ^[1]; Murphy, Karen E. ^[1]; Denton, David L. ^[1]; Garland, Marc A. ^[1]; Mirzadeh, Saed ^[1]; Hogle, Susan ^[1]; Owens, Allison ^[1]

Oak Ridge National Lab. (ORNL), Oak Ridge, TN (United States)

Limited availability of ²²⁹Th for clinical applications of ²¹³Bi necessitates investigation of alternative production routes. In reactor production, ²²⁹Th is produced from neutron transmutation of ²²⁶Ra, ²²⁸Ra, ²²⁷Ac and ²²⁸Th. Here, we evaluate irradiations of ²²⁶Ra, ²²⁸Ra, and ²²⁷Ac targets at the ORNL High Flux Isotope Reactor.

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Research Organization:: Oak Ridge National Laboratory (ORNL), Oak Ridge, TN (United States)

Sponsoring Organization:: USDOE Office of Nuclear Energy (NE)

Grant/Contract Number:: AC05-00OR22725

OSTI ID:: 1253240

Alternate ID(s):: OSTI ID: 1358796

Journal Information:: Applied Radiation and Isotopes, Vol. 114, Issue C; ISSN 0969-8043

Publisher:: ElsevierCopyright Statement

Country of Publication:: United States

Language:: English

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Cited by: 20 works

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References (18)

Cyclotron production of Ac-225 for targeted alpha therapy11Dedicated to Prof. Dr. Franz Baumgärtner on the occasion of his 75th birthday. Apostolidis, C.; Molinet, R.; McGinley, J. Applied Radiation and Isotopes, Vol. 62, Issue 3 https://doi.org/10.1016/j.apradiso.2004.06.013	journal	March 2005
Production of Ac-225 from Th-229 for Targeted α Therapy Apostolidis, C.; Molinet, R.; Rasmussen, G. Analytical Chemistry, Vol. 77, Issue 19 https://doi.org/10.1021/ac0580114	journal	October 2005
Production of actinium-225 for alpha particle mediated radioimmunotherapy Boll, Rose A.; Malkemus, Dairin; Mirzadeh, Saed Applied Radiation and Isotopes, Vol. 62, Issue 5 https://doi.org/10.1016/j.apradiso.2004.12.003	journal	May 2005
Reactor Production of Thorium-229 Boll, Rose A. INTERNATIONAL CONFERENCE ON NUCLEAR DATA FOR SCIENCE AND TECHNOLOGY, AIP Conference Proceedings https://doi.org/10.1063/1.1945330	conference	January 2005
New Treatment Option: 223Ra Chloride, the First Approved Unsealed α-Emitting Radiopharmaceutical Colletti, Patrick M. Clinical Nuclear Medicine, Vol. 38, Issue 9 https://doi.org/10.1097/RLU.0b013e3182a2dd53	journal	January 2013
Thorium-229 for Medical Applications Du, Miting; Peretz, Fred; Boll, Rose A. Radioanalytical Methods in Interdisciplinary Research https://doi.org/10.1021/bk-2004-0868.ch013	book	November 2003
Measurement of cross sections for the [sup 232]Th(P,4n)[sup 229]Pa reaction at low proton energies Jost, C. U.; Griswold, J. R.; Bruffey, S. H. APPLICATION OF ACCELERATORS IN RESEARCH AND INDUSTRY: Twenty-Second International Conference, AIP Conference Proceedings https://doi.org/10.1063/1.4802383	conference	January 2013
An overview of targeted alpha therapy Kim, Young-Seung; Brechbiel, Martin W. Tumor Biology, Vol. 33, Issue 3 https://doi.org/10.1007/s13277-011-0286-y	journal	December 2011
Yields of activation products in 226Ra irradiation in the high-flux SM reactor Kuznetsov, R. A.; Butkalyuk, P. S.; Tarasov, V. A. Radiochemistry, Vol. 54, Issue 4 https://doi.org/10.1134/S1066362212040121	journal	July 2012
Neutron dosimetry of the HFIR hydraulic facility Mahmood, S. T.; Mirzadeh, S.; Farrell, K. https://doi.org/10.2172/34421	report	February 1995
Realizing the potential of the Actinium-225 radionuclide generator in targeted alpha particle therapy applications Miederer, Matthias; Scheinberg, David A.; McDevitt, Michael R. Advanced Drug Delivery Reviews, Vol. 60, Issue 12 https://doi.org/10.1016/j.addr.2008.04.009	journal	September 2008
Generator-produced alpha-emitters Mirzadeh, Saed Applied Radiation and Isotopes, Vol. 49, Issue 4 https://doi.org/10.1016/S0969-8043(97)00175-9	journal	April 1998
Decay of 37.5-min ${}^{236}{Th}$ and 9.1-min ${}^{236}{Pa}$ Mirzadeh, S.; Chu, Y. Y.; Katcoff, S. Physical Review C, Vol. 29, Issue 3 https://doi.org/10.1103/PhysRevC.29.985	journal	March 1984
Decay of 7.3-min ${}^{235}{Th}$ and 24.6-min ${}^{235}{Pa}$ Mirzadeh, S.; Chu, Y. Y.; Katcoff, S. Physical Review C, Vol. 33, Issue 6 https://doi.org/10.1103/PhysRevC.33.2159	journal	June 1986
Numerical evaluation of the production of radionuclides in a nuclear reactor (Part II) Mirzadeh, Saed; Walsh, Phillip Applied Radiation and Isotopes, Vol. 49, Issue 4 https://doi.org/10.1016/S0969-8043(97)00288-1	journal	April 1998
225Ac and 223Ra production via 800MeV proton irradiation of natural thorium targets Weidner, J. W.; Mashnik, S. G.; John, K. D. Applied Radiation and Isotopes, Vol. 70, Issue 11 https://doi.org/10.1016/j.apradiso.2012.07.003	journal	November 2012
Proton-induced cross sections relevant to production of 225Ac and 223Ra in natural thorium targets below 200MeV Weidner, J. W.; Mashnik, S. G.; John, K. D. Applied Radiation and Isotopes, Vol. 70, Issue 11 https://doi.org/10.1016/j.apradiso.2012.07.006	journal	November 2012
Production of ²²⁵Ac and ²²³Ra by irradiation of Th with accelerated protons Zhuikov, B. L.; Kalmykov, S. N.; Ermolaev, S. V. Radiochemistry, Vol. 53, Issue 1, p. 73-80 https://doi.org/10.1134/S1066362211010103	journal	February 2011

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Development of ²²⁵ Ac Radiopharmaceuticals: TRIUMF Perspectives and Experiences Robertson, Andrew Kyle Henderson; Ramogida, Caterina Fortunata; Schaffer, Paul Current Radiopharmaceuticals, Vol. 11, Issue 3 https://doi.org/10.2174/1874471011666180416161908	journal	October 2018

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