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Title: Structural and Inhibitory Effects of Hinge Loop Mutagenesis in Serpin-2 from the Malaria Vector Anopheles gambiae

Journal Article · · J. Biol. Chem.

Research Organization:
Argonne National Laboratory (ANL), Argonne, IL (United States). Advanced Photon Source (APS)
Sponsoring Organization:
USDOE Office of Science (SC), Basic Energy Sciences (BES); National Institutes of Health (NIH)
Grant/Contract Number:
AC02-06CH11357
OSTI ID:
1170448
Journal Information:
J. Biol. Chem., Vol. 290, Issue (5) ; 01, 2015
Country of Publication:
United States
Language:
ENGLISH
Citation Metrics:
Cited by: 6 works
Citation information provided by
Web of Science

References (72)

A global map of dominant malaria vectors journal April 2012
A new world malaria map: Plasmodium falciparum endemicity in 2010 journal December 2011
Air temperature suitability for Plasmodium falciparum malaria transmission in Africa 2000-2012: a high-resolution spatiotemporal prediction journal May 2014
Global, regional, and national incidence and mortality for HIV, tuberculosis, and malaria during 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 journal September 2014
Malaria Management: Past, Present, and Future journal January 2010
Mutations in the voltage-gated sodium channel gene of anophelines and their association with resistance to pyrethroids – a review journal January 2014
An online tool for mapping insecticide resistance in major Anopheles vectors of human malaria parasites and review of resistance status for the Afrotropical region journal January 2014
How to Make Evolution-Proof Insecticides for Malaria Control journal April 2009
Chapter 12 Microsporidians as Evolution‐Proof Agents of Malaria Control? book January 2009
Anopheles gambiae SRPN2 facilitates midgut invasion by the malaria parasite Plasmodium berghei journal September 2005
Characterization of a regulatory unit that controls melanization and affects longevity of mosquitoes journal October 2010
Anopheles gambiae innate immunity journal January 2010
Mosquito Immunity book January 2010
Malaria Immunity in Man and Mosquito: Insights into Unsolved Mysteries of a Deadly Infectious Disease journal March 2014
Melanization immune responses in mosquito vectors journal April 2005
Two Proteases Defining a Melanization Cascade in the Immune System of Drosophila journal July 2006
Prophenoloxidase-activating Enzyme of the Silkworm, Bombyx mori: PURIFICATION, CHARACTERIZATION, AND cDNA CLONING journal March 1999
Molecular Control of Phenoloxidase-induced Melanin Synthesis in an Insect journal July 2008
Proteolytic cascades and their involvement in invertebrate immunity journal October 2010
The Roles of Two Clip Domain Serine Proteases in Innate Immune Responses of the Malaria Vector Anopheles gambiae journal September 2005
Prophenoloxidase-activating proteinase-3 (PAP-3) from Manduca sexta hemolymph: a clip-domain serine proteinase regulated by serpin-1J and serine proteinase homologs journal October 2003
Pro-phenol oxidase activating proteinase from an insect, Manduca sexta: A bacteria-inducible protein similar to Drosophila easter journal October 1998
Insect prophenoloxidase: the view beyond immunity journal July 2014
Prophenoloxidase Activation: Nonself Recognition and Cell Cooperation in Insect Immunity journal November 1984
The roles of serpins in mosquito immunology and physiology journal February 2013
Regulation of Proteases by Protein Inhibitors of the Serpin Superfamily book January 2011
Serpin Structure, Mechanism, and Function journal November 2002
Crystallography of Serpins and Serpin Complexes book January 2011
Structure of a serpin–protease complex shows inhibition by deformation journal October 2000
Crystal structure of native Anopheles gambiae serpin-2, a negative regulator of melanization in mosquitoes: Crystal Structure of Anopheles SRPN2 journal April 2011
Structure of β-Antithrombin and the Effect of Glycosylation on Antithrombin's Heparin Affinity and Activity journal February 2003
The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions journal January 1994
Crystal structures of native and thrombin-complexed heparin cofactor II reveal a multistep allosteric mechanism journal August 2002
The Murine Orthologue of Human Antichymotrypsin: A STRUCTURAL PARADIGM FOR CLADE A3 SERPINS journal September 2005
Structural and Functional Characterization of a Highly Specific Serpin in the Insect Innate Immunity journal November 2010
The anticoagulant activation of antithrombin by heparin journal December 1997
Residues Tyr 253 and Glu 255 in Strand 3 of β-Sheet C of Antithrombin Are Key Determinants of an Exosite Made Accessible by Heparin Activation to Promote Rapid Inhibition of Factors Xa and IXa journal March 2006
Antithrombin–S195A factor Xa-heparin structure reveals the allosteric mechanism of antithrombin activation journal April 2006
Mechanism of Heparin Activation of Antithrombin. Evidence for Reactive Center Loop Preinsertion with Expulsion upon Heparin Binding journal January 1996
Molecular mechanisms of antithrombin–heparin regulation of blood clotting proteinases. A paradigm for understanding proteinase regulation by serpin family protein proteinase inhibitors journal November 2010
Allosteric Activation of Antithrombin Critically Depends upon Hinge Region Extension journal August 2004
Conformational Conversion of Antithrombin to a Fully Activated Substrate of Factor Xa without Need for Heparin journal March 1998
Serine 380 (P14) → Glutamate Mutation Activates Antithrombin as an Inhibitor of Factor Xa journal February 2000
Expression and characterization of recombinant Manduca sexta serpin- 1B and site-directed mutants that change its inhibitory selectivity journal December 1995
Automatic indexing of rotation diffraction patterns journal February 1988
An introduction to data reduction: space-group determination, scaling and intensity statistics journal March 2011
Phaser crystallographic software journal July 2007
PHENIX: a comprehensive Python-based system for macromolecular structure solution journal January 2010
Molecular replacement with MOLREP journal December 2009
Features and development of Coot journal March 2010
Optimal description of a protein structure in terms of multiple groups undergoing TLS motion journal March 2006
MolProbity : all-atom structure validation for macromolecular crystallography journal December 2009
Developments in the CCP 4 molecular-graphics project journal November 2004
Correction of X-ray intensities from single crystals containing lattice-translocation defects journal December 2004
Refinement of Macromolecular Structures by the Maximum-Likelihood Method journal May 1997
Squamous Cell Carcinoma Antigen 2 Is a Novel Serpin That Inhibits the Chymotrypsin-like Proteinases Cathepsin G and Mast Cell Chymase journal January 1997
Effect of covalent antithrombin-heparin on activated protein C inactivation by protein C inhibitor journal June 2010
Secondary-structure matching (SSM), a new tool for fast protein structure alignment in three dimensions journal November 2004
Phylogeny of the Serpin Superfamily: Implications of Patterns of Amino Acid Conservation for Structure and Function journal November 2000
.alpha.1-Proteinase Inhibitor Variant T345R. Influence of P14 Residue on Substrate and Inhibitory Pathways journal July 1994
The Allosteric Mechanism of Activation of Antithrombin as an Inhibitor of Factor IXa and Factor Xa: HEPARIN-INDEPENDENT FULL ACTIVATION THROUGH MUTATIONS ADJACENT TO HELIX D journal September 2013
A Serine Proteinase Homologue, SPH-3, Plays a Central Role in Insect Immunity journal March 2011
Manduca sexta prophenoloxidase (proPO) activation requires proPO-activating proteinase (PAP) and serine proteinase homologs (SPHs) simultaneously journal March 2005
The CLIP-Domain Serine Protease Homolog SPCLIP1 Regulates Complement Recruitment to Microbial Surfaces in the Malaria Mosquito Anopheles gambiae journal September 2013
A genetic module regulates the melanization response of Anopheles to Plasmodium journal September 2006
Nonproteolytic serine proteinase homologs are involved in prophenoloxidase activation in the tobacco hornworm, Manduca sexta journal February 2003
Scaling and assessment of data quality journal December 2005
Improved R-factors for diffraction data analysis in macromolecular crystallography journal April 1997
Global indicators of X-ray data quality journal April 2001
Linking Crystallographic Model and Data Quality journal May 2012
Resolving Some Old Problems in Protein Crystallography journal May 2012
Site-directed, Ligase-Independent Mutagenesis (SLIM): a single-tube methodology approaching 100% efficiency in 4 h journal November 2004

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Molecular characterization of serine protease inhibitor isoform 3, SmSPI, from Schistosoma mansoni journal April 2016

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