Structure and inhibition of EV-D68, a virus that causes respiratory illness in children
- Purdue Univ., West Lafayette, IN (United States). Hockmeyer Hall of Structural Biology. Dept. of Biological Sciences
- Purdue Univ., West Lafayette, IN (United States). Hockmeyer Hall of Structural Biology. Dept. of Biological Sciences. Dept. of Computer Science
Enterovirus D68 (EV-D68) is a member of Picornaviridae and is a causative agent of recent outbreaks of respiratory illness in children in the United States. We report in this paper the crystal structures of EV-D68 and its complex with pleconaril, a capsid-binding compound that had been developed as an anti-rhinovirus drug. The hydrophobic drug-binding pocket in viral protein 1 contained density that is consistent with a fatty acid of about 10 carbon atoms. This density could be displaced by pleconaril. Finally, we also showed that pleconaril inhibits EV-D68 at a half-maximal effective concentration of 430 nanomolar and might, therefore, be a possible drug candidate to alleviate EV-D68 outbreaks.
- Research Organization:
- Purdue Univ., West Lafayette, IN (United States)
- Sponsoring Organization:
- USDOE Office of Science (SC), Basic Energy Sciences (BES); National Inst. of Health (NIH) (United States)
- Grant/Contract Number:
- AC02-06CH11357; RR007707; AI11219
- OSTI ID:
- 1168487
- Journal Information:
- Science, Vol. 347, Issue 6217; ISSN 0036-8075
- Publisher:
- AAASCopyright Statement
- Country of Publication:
- United States
- Language:
- ENGLISH
Cited by: 111 works
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