Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules

Adamec, Jiri; Yang, Wen-Chu; Regnier, Fred E

Title: Group specific internal standard technology (GSIST) for simultaneous identification and quantification of small molecules

Patent · Tue Jan 14 00:00:00 EST 2014

OSTI ID:1117679

Adamec, Jiri; Yang, Wen-Chu; Regnier, Fred E

Reagents and methods are provided that permit simultaneous analysis of multiple diverse small molecule analytes present in a complex mixture. Samples are labeled with chemically identical but isotopically distince forms of the labeling reagent, and analyzed using mass spectrometry. A single reagent simultaneously derivatizes multiple small molecule analytes having different reactive functional groups.

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Research Organization:: Purdue Research Foundation, West Lafayette, IN, USA

Sponsoring Organization:: USDOE

DOE Contract Number:: FC36-07GO17059

Assignee:: Purdue Research Foundation (West Lafayette, IN)

Patent Number(s):: 8,628,977

Application Number:: 12/990,560

OSTI ID:: 1117679

Resource Relation:: Patent File Date: 2009 May 01

Country of Publication:: United States

Language:: English

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