Reproducibility of Global and Local Reconstruction of Three-Dimensional Micro-Computed Tomography of Iliac Crest Biopsies
Variation in computed tomography (CT) image grayscale and spatial geometry due to specimen orientation, magnification, voxel size, differences in X-ray photon energy and limited field-of-view during the scan, were evaluated in repeated micro-CT scans of iliac crest biopsies and test phantoms. Using the micro-CT scanner on beamline X2B at the Brookhaven National Laboratory's National Synchrotron Light Source, 3-D micro-CT images were generated. They consisted of up to 1024 X 24002, 4-mum cubic voxels, each with 16-bit gray-scale. We also reconstructed the images at 16-, 32-, and 48-mum voxel resolution. Scan data were reconstructed from the complete profiles using filtered back-projection and from truncated profiles using profile-extension and with a Local reconstruction algorithm. Three biopsies and one bonelike test phantom were each rescanned at three different times at annual intervals. For the full-data-set reconstructions, the reproducibility of the estimates of mineral content of bone at mean bone opacity value, was {+-}28.8 mg/cm3, i.e., 2.56%, in a 4-mum cubic voxel at the 95% confidence level. The reproducibility decreased with increased voxel size. The interscan difference in imaged bone volume ranged from 0.86 {+-} 0.64% at 4-mum voxel resolution, and 2.64 {+-} 2.48% at 48 mum.
- Research Organization:
- Brookhaven National Lab. (BNL), Upton, NY (United States). National Synchrotron Light Source
- Sponsoring Organization:
- Doe - Office Of Science
- DOE Contract Number:
- DE-AC02-98CH10886
- OSTI ID:
- 960172
- Report Number(s):
- BNL-83158-2009-JA; ITMID4; TRN: US1005914
- Journal Information:
- IEEE Transactions on Medical Imaging, Vol. 27, Issue 4; ISSN 0278-0062
- Country of Publication:
- United States
- Language:
- English
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