Failure to find linkage between a functional polymorphism in the dopamine D4 receptor gene and schizophrenia

Journal Article · Tue Mar 15 00:00:00 EST 1994 · American Journal of Medical Genetics

DOI:https://doi.org/10.1002/ajmg.1320540104· OSTI ID:91059

Shaikh, S; Gill, M; Collier, D A ^[1]

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1. Institute of Psychiatry, London (United Kingdom); and others

We report the results of a linkage study in 24 families multiply affected with schizophrenia using a polymorphic DNA sequence encoding the third cytoplasmic loop of the dopamine D4 receptor. Two-point LOD score analyses with a range of single gene models ranging from near dominant to near recessive revealed no evidence for linkage. In addition, we examined the data by non-parametric sib-pair analysis and found no excess sharing of alleles between affected sib-pairs. We therefore conclude that mutations within the dopamine D4 receptor gene do not have a major aetiological role in schizophrenia in our collection of pedigrees. 20 refs., 2 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 91059
• Journal Information: American Journal of Medical Genetics, Vol. 54, Issue 1; Other Information: PBD: 15 Mar 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
PATIENTS
MENTAL DISORDERS
ETIOLOGY
GENES
GENE MUTATIONS
DOPAMINE
RECEPTORS
GENETICS
POLYMERASE CHAIN REACTION
DNA SEQUENCING
STATISTICS