DNA fragmentation induced by fe ions in human cells: shielding influence on spatially correlated damage
Outside the magnetic field of the Earth, high energy heavy ions constitute a relevant part of the biologically significant dose to astronauts during the very long travels through space. The typical pattern of energy deposition in the matter by heavy ions on the microscopic scale is believed to produce spatially correlated damage in the DNA which is critical for radiobiological effects. We have investigated the influence of a lucite shielding on the initial production of very small DNA fragments in human fibroblasts irradiated with 1 GeV/u iron (Fe) ions. We also used small gamma, Greek-rays as reference radiation. Our results show: (1) a lower effect per incident ion when the shielding is used; (2) an higher DNA Double Strand Breaks (DSB) induction by Fe ions than by small gamma, Greek-rays in the size range 123 kbp; (3) a non-random DNA DSB induction by Fe ions.
- Research Organization:
- Lawrence Berkeley National Lab. (LBNL), Berkeley, CA (United States)
- Sponsoring Organization:
- US Department of Energy (US)
- DOE Contract Number:
- AC03-76SF00098
- OSTI ID:
- 835829
- Report Number(s):
- LBNL-56788; TRN: US0500406
- Journal Information:
- Advances in Space Research, Vol. 34, Issue 6; Other Information: Journal Publication Date: 04/02/2004; PBD: 19 Nov 2003
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
74 ATOMIC AND MOLECULAR PHYSICS
ANIMAL CELLS
BIOLOGICAL RADIATION EFFECTS
DNA
FIBROBLASTS
FRAGMENTATION
HEAVY IONS
INDUCTION
IRON
LUCITE
MAGNETIC FIELDS
PRODUCTION
SHIELDING
STRAND BREAKS
RADIATION RISK
DNA FRAGMENTATION
FE IONS IN HUMAN CELLS
RADIATION SHIELDING
RADIATION DOSE