Final Report: Bone Mass Inheritance: A Project to Identify the Genetic Regulation of Bone Mass
This project was designed to find human chromosomal locations that contain genes regulating peak bone density. It is part of a whole genome search for those loci,each responsible for at least 15% of the variation in the peak adult bone density. We accomplished this with a sib pair design, combined with simultaneous examination of extended kindreds. This project gave partial support of the recruitment which has now been completed. The project will extend into 2003. During the remainder of the project, a whole genome scan will be performed from the entire cohort of 2226 persons who have DNA archived, followed by linkage analysis. This project will meet the scientific objective leading eventually to expanded options for treating the condition that leads to bone thinning osteoporosis, and potential fractures in aging populations.
- Research Organization:
- Creighton University (US)
- Sponsoring Organization:
- USDOE Office of Energy Research (ER) (US)
- DOE Contract Number:
- FG03-00ER63000
- OSTI ID:
- 793992
- Resource Relation:
- Other Information: PBD: 28 Mar 2002
- Country of Publication:
- United States
- Language:
- English
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