The selective bioaccumulation of some components of technical chlordane in human breast tissue
- Indiana Univ., Bloomington (USA)
General use of technical grade chlordane has led to wide exposure of the general populace to this toxic mixture. In an attempt to assess this exposure, the various components of technical chlordane were identified, and some were quantitated in fifteen human breast tissue using electron capture, negative ionization mass spectrometry coupled with capillary gas chromatography (ECNI GC/MS). It was found that trans- and cis-nonachlor, a third nonachlor isomer, and structurally unknown chlordane-like components of technical chlordane are retained in human breast tissue in greater abundance than the gamma and alpha isomers of chlordane. Relative bioaccumulation factors were 30 to 250 times the relative bioaccumulation of the gamma and alpha chlordanes, as compared to a technical chlordane standard. Compounds that could be quantitated include: cis-nonachlor at 14-90 ng/g fat, trans-nonachlor at 200-1000 ng/g fat, gamma-chlordane at 2-10 ng/g fat, and alpha-chlordane at 2-13 ng/g fat. A possible mechanism of discrimination is differential metabolism of the various carbon skeletons derived from the isomers of chlordene. It is well-known that the chlordene starting material has various distinct structural analogs. These different analogs, when chlorinated further, may have quite different rates of metabolism.
- OSTI ID:
- 7266306
- Report Number(s):
- CONF-8809264-; CODEN: ACWCA
- Journal Information:
- Preprints of Papers Presented at National Meeting, Division of Water, Air and Waste Chemistry, American Chemical Society; (USA), Vol. 28:2; Conference: American Chemical Society Division of Environmental Chemistry, Los Angeles, CA (USA), 25-30 Sep 1988; ISSN 0099-7293
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CHLORINATED AROMATIC HYDROCARBONS
BIOLOGICAL ACCUMULATION
MAMMARY GLANDS
QUANTITATIVE CHEMICAL ANALYSIS
ELECTRON CAPTURE
EXPERIMENTAL DATA
GAS CHROMATOGRAPHY
ISOMERS
MASS SPECTROSCOPY
METABOLISM
TOXIC MATERIALS
AROMATICS
BODY
CAPTURE
CHEMICAL ANALYSIS
CHROMATOGRAPHY
DATA
GLANDS
HALOGENATED AROMATIC HYDROCARBONS
INFORMATION
MATERIALS
NUMERICAL DATA
ORGANIC CHLORINE COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANS
SEPARATION PROCESSES
SPECTROSCOPY
560300* - Chemicals Metabolism & Toxicology