Selenium deficiency induced by zinc deprivation in a crustacean

Journal Article · Tue Aug 01 00:00:00 EDT 1989 · Proceedings of the National Academy of Sciences of the United States of America; (USA)

DOI:https://doi.org/10.1073/pnas.86.16.6436· OSTI ID:7167048

Keating, K I; Caffrey, P B ^[1]

---

1. Rutgers the State Univ. of New Jersey, New Brunswick (USA)

For intact daphnids reared in circumstances of controlled trace element exposure, one consequence of insufficient zinc (Zn) is an increased demand on the animal's pool of available selenium (Se). This demand is manifested by the type of cuticle deterioration associated with Se deficiency and by a depression of reproduction. In the presence of 25 parts per billion (ppb) Zn, 1 ppb Se eliminates these symptoms. In the absence of detectable Zn, 5 ppb Se eliminates overt cuticle damage and substantially increases reproduction. A shortening of life span resulting from Zn deprivation is not ameliorated by Se addition. The authors suggest that the interplay between Zn and Se concentrations reflects an underlying interplay between interdependent, but distinct, metabolic pathways; i.e., (for Se) glutathione peroxidase and (for Zn) Cu,Zn-superoxide dismutase--each offering protection against free radical damage. Because they are not necessarily localized in a given tissue, the key to recognition of such subtle, complex trace nutrient interactions has been use of intact animals in circumstances of control previously attainable only in tissue cultures.

• OSTI ID: 7167048
• Journal Information: Proceedings of the National Academy of Sciences of the United States of America; (USA), Vol. 86:16; ISSN 0027-8424
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
SELENIUM COMPOUNDS
METABOLISM
SUPEROXIDE DISMUTASE
BIOCHEMISTRY
ZINC COMPOUNDS
NUTRITIONAL DEFICIENCY
COPPER COMPOUNDS
DAPHNIA
RADICALS
TRACE AMOUNTS
ANIMALS
AQUATIC ORGANISMS
ARTHROPODS
BRANCHIOPODS
CHEMISTRY
CRUSTACEANS
ENZYMES
INVERTEBRATES
OXIDOREDUCTASES
TRANSITION ELEMENT COMPOUNDS
560300* - Chemicals Metabolism & Toxicology