Comparative study of various methods used for determined health effects of inhaled sulfates

Journal Article · Sun Dec 01 00:00:00 EST 1985 · Environ. Res.; (United States)

OSTI ID:7163794

Drummond, J G; Aranyi, C; Schiff, L J; Fenters, J D; Graham, J A

Various health effect parameters were compared to determine which tests were the most sensitive indicators of toxic effects of exposure to metallic sulfate aerosols. Inhalation studies were conducted involving either single 3-hr exposure to various concentrations of cupric sulfate (0.43-2.64 mg/m/sup 3/ SO/sub 4/), aluminum sulfate (1.65-2.75 mg/m/sup 3/ SO/sub 4/), and aluminum ammonium sulfate (1.47-3.81 mg/m/sup 3/ SO/sub 4/) or multiple (five and ten) daily 3-hr exposures to cupric sulfate (0.1 mg/m/sup 3/ SO/sub 4/). The test parameters studied in male and female CD/sub 1/ mice were changes in mortality after respiratory infection with Group C Streptococcus zooepidemicus; pulmonary bactericidal activity; pulmonary cell number, type, viability, and ATP content; and pulmonary morphology by scanning electron microscopy. Tracheal ciliary beating frequency and morphology were also studied in both CD/sup 1/ mice and Syrian golden hamsters. Differences in bacteria-induced mortality rate appeared to be the most sensitive and consistent indicators of pollutant damage. The other parameters produced evidence of damage but generally only at the higher pollutant concentrations. Cupric sulfate was the most toxic of the three sulfates, but the differences between the toxicity of the aluminum sulfate and aluminum ammonium sulfate were less clear.

• Research Organization: IIT Research Institute, Chicago, IL
• OSTI ID: 7163794
• Journal Information: Environ. Res.; (United States), Vol. 38:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
RESPIRATORY SYSTEM
INJURIES
SULFATES
TOXICITY
ALUMINIUM SULFATES
AMMONIUM SULFATES
COMPARATIVE EVALUATIONS
COPPER SULFATES
DOSE-RESPONSE RELATIONSHIPS
HAMSTERS
INFECTIVITY
INHALATION
LUNGS
MICE
MORPHOLOGICAL CHANGES
MORTALITY
STREPTOCOCCUS
ALUMINIUM COMPOUNDS
AMMONIUM COMPOUNDS
ANIMALS
BACTERIA
BODY
COPPER COMPOUNDS
INTAKE
MAMMALS
MICROORGANISMS
ORGANS
OXYGEN COMPOUNDS
RODENTS
SULFUR COMPOUNDS
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology