Effects of acidic mixtures on pulmonary macrophage functions: A pilot study. Final report
Technical Report
·
OSTI ID:7099339
Fischer 344 rats were examined for effects of inhaled nitric acid and ozone on macrophage cell function, to evaluate new endpoints for future acid inhalation studies. Pulmonary macrophage respiratory burst activity, production of arachidonic acid metabolites (leukotriene B4 and leukotriene C4) by macrophages, and lavage fluid elastase inhibitory capacity were found to be affected by in vivo exposure to nitric acid vapor, alone or in combination with ozone. These results have implications with respect to the development of lung infections, asthma, and emphysema.
- Research Organization:
- California Univ., Irvine, CA (United States). Dept. of Community and Environmental Medicine
- OSTI ID:
- 7099339
- Report Number(s):
- PB-94-218880/XAB; CNN: ARB-A933-078
- Country of Publication:
- United States
- Language:
- English
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