Pathogenesis of the delayed phase of Rauscher virus-induced thrombocytopenia

Journal Article · Wed Jan 01 00:00:00 EST 1986 · J. Immunol.; (United States)

OSTI ID:7085402

Grau, G E; Morrow, D; Izui, S; Lambert, P H

BALB/c (H-2/sup d/) mice injected with Rauscher murine leukemia virus (RMuLV) developed two phases of thrombocytopenia: an acute phase, probably due to direct virus-platelet interactions, and a delayed phase, starting 2 to 3 wk after virus injection, which was associated with the infection of megakaryocytes by RMuLV and with the expression of RMuLV gp70 and p30 antigens on platelet membranes. This study was concerned with the pathogenesis of this second phase of thrombocytopenia. During this period, the number of marrow megakaryocytes was increased. A peripheral platelet destruction was further indicated by reduced platelet life span. It was shown that radiolabeled platelets, either normal or infected, were submitted to a more rapid clearance in infected recipients than in normal recipients. This might be due to the splenomegaly observed in infected recipients. However, the immediate clearance of gp70/sup +/ platelets was more accelerated in infected recipients with high titers of serum anti-gp70 antibodies than in infected recipients without detectable serum anti-gp70 antibodies. These results suggest that specific clearance of gp70/sup +/ platelets in the presence of significant amounts of serum antiviral antibodies and nonspecific hypersplenism play a role in the development of delayed thrombocytopenia in RMuLV-infected mice.

• Research Organization: Univ. of Geneva, Switzerland
• OSTI ID: 7085402
• Journal Information: J. Immunol.; (United States), Vol. 136:2
• Country of Publication: United States
• Language: English

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551001* - Physiological Systems- Tracer Techniques