Decrease in plasma high-density lipoprotein cholesterol levels at puberty in boys with delayed adolescence: correlation with plasma testosterone levels

Journal Article · Fri Jan 23 00:00:00 EST 1987 · JAMA, J. Am. Med. Assoc.; (United States)

DOI:https://doi.org/10.1001/jama.1987.03390040118029· OSTI ID:7065259

Kirkland, R T; Keenan, B S; Probstfield, J L; Patsch, W; Lin, T L; Clayton, G W; Insull, W Jr

A three-phase study tested the hypothesis that the decrease in the high-density lipoprotein cholesterol (HDL-C) level observed in boys at puberty is related to an increase in the plasma testosterone concentration. In phase I, 57 boys aged 10 to 17 years were categorized into four pubertal stages based on clinical parameters and plasma testosterone levels. These four groups showed increasing plasma testosterone values and decreasing HDL-C levels. In phase II, 14 boys with delayed adolescence were treated with testosterone enanthate. Plasma testosterone levels during therapy were in the adult male range. Levels of HDL-C decreased by a mean of 7.4 mg/dL (0.20 mmol/L) and 13.7 mg/dL (0.35 mmol/L), respectively, after the first two doses. In phase III, 13 boys with delayed adolescence demonstrated increasing plasma testosterone levels and decreasing HDL-C levels during spontaneous puberty. Levels of HDL-C and apolipoprotein A-1 were correlated during induced and spontaneous puberty. Testosterone should be considered a significant determinant of plasma HDL-C levels during pubertal development.

• Research Organization: Baylor College of Medicine, Houston, TX
• OSTI ID: 7065259
• Journal Information: JAMA, J. Am. Med. Assoc.; (United States), Vol. 257:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
LIPOPROTEINS
RADIOIMMUNOASSAY
TESTOSTERONE
ADOLESCENTS
BLOOD CHEMISTRY
BLOOD PLASMA
CHOLESTEROL
MALES
AGE GROUPS
ANDROGENS
ANDROSTANES
BIOLOGICAL MATERIALS
BLOOD
BODY FLUIDS
HORMONES
HYDROXY COMPOUNDS
IMMUNOASSAY
IMMUNOLOGY
ISOTOPE APPLICATIONS
KETONES
LIPIDS
MATERIALS
ORGANIC COMPOUNDS
PROTEINS
RADIOASSAY
RADIOIMMUNOLOGY
STEROID HORMONES
STEROIDS
STEROLS
TRACER TECHNIQUES
550601* - Medicine- Unsealed Radionuclides in Diagnostics