Quantification of morphologic, cytologic, and kinetic parameters of unirradiated swine skin: a histologic model

Journal Article · Tue May 01 00:00:00 EDT 1984 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3576234· OSTI ID:7054473

Archambeau, J O; Bennett, G W

This study determines multiple histologic and cell kinetic parameters of unirradiated swine skin. The prickle cell layer exists as a shell three to six cells thick. The proliferative basal layer exists as a confluent monolayer with 2031 +/- 48 cells/cm; it has delta growth fraction of 1, an average cell generation time of 12 days, a T/sub s/ of 9 hr, and a T/sub s/ + T/sub G2/ + T/sub 1/2M/ of 17 to 19 hr. The labeling index is 3.9% with a diurnal variation having a 5% peak at 1800 hr and a 2.5% nadir at 0900-1100 hr. The mitotic index varies from 1.7 to 3.2% and has no clear-cut diurnal variation. These values are similar to those available for man. These data and those published previously are utilized to define a histologic model of the irradiated epidermal cell renewal system. These measured values are compared with those derived from analysis of available time-dose isoeffect data using a single-hit multitarget and a linear-quadratic model.

• Research Organization: City of Hope National Medical Center, Duarte, CA
• OSTI ID: 7054473
• Journal Information: Radiat. Res.; (United States), Vol. 98:2
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CELL CYCLE
BIOLOGICAL MODELS
DAILY VARIATIONS
KINETICS
SKIN
HISTOLOGY
POPULATION DYNAMICS
AUTORADIOGRAPHY
BIOPSY
ERYTHEMA
MITOTIC INDEX
SWINE
TRITIUM COMPOUNDS
ANIMALS
BODY
DIAGNOSTIC TECHNIQUES
DOMESTIC ANIMALS
LABELLED COMPOUNDS
MAMMALS
ORGANS
SYMPTOMS
VARIATIONS
VERTEBRATES
560152* - Radiation Effects on Animals- Animals