Metabolism of phencyclidine

Thesis/Dissertation · Thu Jan 01 00:00:00 EST 1987

OSTI ID:7026807

Hoag, M K.P.

Phencyclidine (PCP) is a drug of abuse which may produce, in some users, a persistent schizophreniform psychosis. The possibility that long term effects of PCP are mediated by metabolic activation of the parent compound to reactive species is consistent with the demonstration of metabolism-dependent covalent binding of radiolabeled PCP in vivo and in vitro to macromolecules in rodent lung, liver, and kidney. Formation of the electrophilic iminium ion metabolite of PCP is believed to be critical for covalent binding since binding was inhibited by cyanide ion at concentrations which did not inhibit metabolism of PCP but did trap the iminium ion to form the corresponding alpha-aminonitrile. The present studies were designed to characterize further the biological fate of PCP by identifying possible macromolecular targets of the reactive metabolite(s).

• Research Organization: California Univ., San Francisco (USA)
• OSTI ID: 7026807
• Resource Relation: Other Information: Thesis (Ph. D.)
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
PIPERIDINES
METABOLISM
KIDNEYS
LIVER
LUNGS
METABOLIC ACTIVATION
METABOLITES
RADIOISOTOPES
RODENTS
TRACER TECHNIQUES
AMINES
ANIMALS
AZINES
BODY
DIGESTIVE SYSTEM
GLANDS
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PYRIDINES
RESPIRATORY SYSTEM
VERTEBRATES
550501* - Metabolism- Tracer Techniques