Molecular cytogenetics: Rosetta Stone for understanding cancer - Twenty-ninth G. H. A. Clowes Memorial Award lecture
- Univ. of Chicago, IL (United States)
This article reviews the progress in the genetic changes that occur within the cancer that are critically involved in the transformation of a normal to a malignant cell. Clearly, to concentrate on genes to the exclusion of cell biology would be too narrow and short-sighted an approach. Nonetheless, the author is convinced that until the genes have isolated that are centrally involved in at least some of the malignant processes in different cell types, one will be unable to answer the fundamental questions about malignant transformation. More importantly, one will be unable to answer the questions with precision. The author limits consideration to those changes that have been detected by analyzing the karyotypic pattern of human cancer cells using chromosome banding, and in particular to those found in leukemia.
- DOE Contract Number:
- FG02-86ER60408
- OSTI ID:
- 7013862
- Journal Information:
- Cancer Research; (United States), Vol. 50; ISSN 0008-5472
- Country of Publication:
- United States
- Language:
- English
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