Stimulation of cell division by argon and Nd:YAG laser trabeculoplasty in cynomolgus monkeys

Journal Article · Mon Jan 01 00:00:00 EST 1990 · Investigative Ophthalmology and Visual Science; (USA)

OSTI ID:6991368

Dueker, D K; Norberg, M; Johnson, D H; Tschumper, R C; Feeney-Burns, L ^[1]

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1. Univ. of Missouri, Columbia (USA)

Although laser treatment of the trabecular meshwork is the most common form of surgery for glaucoma, the tissue response to this therapy is still incompletely understood. We applied argon or Nd:YAG laser to the trabecular meshwork of six monkeys. Cell division was identified by injecting tritiated thymidine into the anterior chamber 24 hr after laser application. Autoradiography of tissue sections revealed significantly more labelled cells in eyes treated with laser than in the untreated controls. In addition, cells in neighboring tissues such as iris, ciliary body and sclera showed labelling in association with laser application. Furthermore, comparison of argon-induced lesions with those caused by pulsed Nd:YAG suggests that there are quantitative and qualitative differences in the response of trabecular meshwork and surrounding tissues to these two forms of laser energy.

• OSTI ID: 6991368
• Journal Information: Investigative Ophthalmology and Visual Science; (USA), Vol. 31:1; ISSN 0146-0404
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
59 BASIC BIOLOGICAL SCIENCES
EYES
CELL DIVISION
LASER RADIATION
BIOLOGICAL EFFECTS
SENSE ORGANS DISEASES
SURGERY
AUTORADIOGRAPHY
COMPARATIVE EVALUATIONS
GAS LASERS
MONKEYS
NEODYMIUM LASERS
THYMIDINE
TRACER TECHNIQUES
ANIMALS
AZINES
BODY
BODY AREAS
DISEASES
ELECTROMAGNETIC RADIATION
FACE
HEAD
HETEROCYCLIC COMPOUNDS
ISOTOPE APPLICATIONS
LASERS
MAMMALS
MEDICINE
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PRIMATES
PYRIMIDINES
RADIATIONS
RIBOSIDES
SENSE ORGANS
SOLID STATE LASERS
VERTEBRATES
560400* - Other Environmental Pollutant Effects
550901 - Pathology- Tracer Techniques