Induction of hepatocellular carcinoma in nonhuman primates by chemical carcinogens

Journal Article · Sun Jan 01 00:00:00 EST 1989 · Cancer Detection and Prevention; (USA)

OSTI ID:6936541

Adamson, R H ^[1]

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1. National Cancer Institute, National Institutes of Health, Bethesda, MD (USA)

Several compounds were evaluated in nonhuman primates for their potential to induce neoplasms, especially hepatocellular carcinoma (HCC). The compounds can be classified into three groups: food contaminants, model rodent carcinogens, and nitrosamines. All three compounds in the food contaminants group, namely, aflatoxin B1, sterigmatocystin, and methylazoxymethanol acetate, induced HCC. None of the model rodent carcinogens tested consistently induced HCC in rhesus and cynomolgus monkeys. Three of four nitrosamines evaluated induced HCC in rhesus and cynomolgus monkeys. One nitrosamine, diethylnitrosamine, is a predictable and potent inducer of HCC and is useful for establishment of a nonhuman primate model for numerous oncologic studies.

• OSTI ID: 6936541
• Journal Information: Cancer Detection and Prevention; (USA), Vol. 14:2; ISSN 0361-090X
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
AFLATOXIN
CARCINOGENESIS
NITROSAMINES
BIOLOGICAL MODELS
CARCINOGENS
HEPATOMAS
MONKEYS
RODENTS
AMINES
ANIMALS
DISEASES
MAMMALS
NEOPLASMS
NITROSO COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PATHOGENESIS
PRIMATES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology