Effect of carnosine on the immunosuppressive effect of histamine
This paper studies the ability of carnosine (beta-imidazole-lactate) to affect histamine-induced immunosuppression of proliferative activity of various lymphocyte subpopulations and the realization of this effect through surface histamine receptors of the cells. The experiments were carried out on mice; lymphocytes were incubated with tritium-labeled thymidine for 4 h, after which their radioactivity was determined on a scintillation counter. The results show that histamine has an inhibitory action on antigen-induced proliferation of T suppressor lymphocytes through H-2 histamine receptors, for this effect was considerably inhibited by the H-2 histamine blockers metiamide, but not by the H-1 histamine blocker mepyramine.
- Research Organization:
- N.I. Pirogov Second Moscow Medical Institute, Moscow
- OSTI ID:
- 6935602
- Journal Information:
- Bull. Exp. Biol. Med. (Engl. Transl.); (United States), Vol. 98:11
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
HISTAMINE
INHIBITION
LYMPHOCYTES
CELL PROLIFERATION
IMMUNOSUPPRESSION
RADIORECEPTOR ASSAY
MICE
SPLEEN
PEPTIDES
BIOLOGICAL EFFECTS
IMMUNE REACTIONS
IMMUNOSUPPRESSIVE DRUGS
RECEPTORS
THYMIDINE
TRITIUM COMPOUNDS
AMINES
ANIMAL CELLS
ANIMALS
AZINES
AZOLES
BIOLOGICAL MATERIALS
BLOOD
BLOOD CELLS
BODY
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DRUGS
HETEROCYCLIC COMPOUNDS
IMIDAZOLES
ISOTOPE APPLICATIONS
LABELLED COMPOUNDS
LEUKOCYTES
MAMMALS
MATERIALS
MEMBRANE PROTEINS
NUCLEOSIDES
NUCLEOTIDES
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PROTEINS
PYRIMIDINES
RIBOSIDES
RODENTS
SOMATIC CELLS
TRACER TECHNIQUES
VERTEBRATES
550301* - Cytology- Tracer Techniques