Characterization of radiation-induced emesis in the ferret

Journal Article · Wed Jun 01 00:00:00 EDT 1988 · Radiat. Res.; (United States)

DOI:https://doi.org/10.2307/3577130· OSTI ID:6922585

King, G L

Forty-eight ferrets (Mustela putorius furo) were individually head-shielded and radiated with bilateral /sup 60/Co gamma radiation at 100 cGy min-1 at doses ranging between 49 and 601 cGy. The emetic threshold was observed at 69 cGy, the ED50 was calculated at 77 cGy, and 100% incidence of emesis occurred at 201 cGy. With increasing doses of radiation, the latency to first emesis after radiation decreased dramatically, whereas the duration of the prodromal period increased. Two other sets of experiments suggest that dopaminergic mechanisms play a minor role in radiation-induced emesis in the ferret. Twenty-two animals were injected either intravenously or subcutaneously with 30 to 300 micrograms/kg of apomorphine. Fewer than 50% of the animals vomited to 300 micrograms/kg apomorphine; central dopaminergic receptor activation was apparent at all doses. Another eight animals received 1 mg/kg domperidone prior to either 201 (n = 4) or 401 (n = 4) cGy radiation and their emetic responses were compared with NaCl-injected-irradiated controls (n = 8). At 201 cGy, domperidone significantly reduced only the total time in emetic behavior. At 401 cGy, domperidone had no salutary effect on radiation-induced emesis. The emetic responses of the ferret to radiation and apomorphine are compared with these responses in other vomiting species.

• Research Organization: Armed Forces Radiobiology Research Institute, Bethesda, MD (USA)
• OSTI ID: 6922585
• Journal Information: Radiat. Res.; (United States), Vol. 114:3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
DOPAMINE
BIOLOGICAL FUNCTIONS
RADIOSENSITIVITY EFFECTS
MAMMALS
BIOLOGICAL RADIATION EFFECTS
VOMITING
RADIOINDUCTION
COBALT 60
GAMMA RADIATION
RADIATION DOSES
RECEPTORS
AMINES
ANIMALS
AROMATICS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
CARDIOTONICS
CARDIOVASCULAR AGENTS
COBALT ISOTOPES
DOSES
DRUGS
ELECTROMAGNETIC RADIATION
FUNCTIONS
HYDROXY COMPOUNDS
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
IONIZING RADIATIONS
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEMBRANE PROTEINS
MINUTES LIVING RADIOISOTOPES
NEUROREGULATORS
NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
PHENOLS
POLYPHENOLS
PROTEINS
RADIATION EFFECTS
RADIATIONS
RADIOISOTOPES
SYMPATHOMIMETICS
SYMPTOMS
VERTEBRATES
YEARS LIVING RADIOISOTOPES
560152* - Radiation Effects on Animals- Animals