Cerebral blood flow in patients with congestive heart failure treated with captopril
The effect of captopril on cerebral blood flow was studied in five patients with severe congestive heart failure and in five control subjects. Cerebral blood flow was measured by inhalation of /sup 133/xenon and registration of its uptake and washout from the brain by single photon emission computer tomography. In addition, cerebral (internal jugular) venous oxygen tension was determined in the controls. The measurements were made before and 15, 60, and 180 minutes after a single oral dose of captopril (6.25 mg in patients with congestive heart failure and 25 mg in controls). Despite a marked decrease in blood pressure, cerebral blood flow increased slightly in the patients with severe congestive heart failure. When a correction was applied to take account of a change in arterial carbon dioxide tension, however, cerebral blood flow was unchanged after captopril administration even in patients with the greatest decrease in blood pressure, in whom a decrease in cerebral blood flow might have been expected. In the controls, blood pressure was little affected by captopril, whereas a slight, but not statistically significant, decrease in cerebral blood flow was observed. The cerebral venous oxygen tension decreased concomitantly.
- Research Organization:
- Department of Neurology, Rigshospitalet, Copenhagen, Denmark
- OSTI ID:
- 6885873
- Journal Information:
- Am. J. Med.; (United States), Vol. 76:5B
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BRAIN
BLOOD FLOW
SINGLE PHOTON EMISSION COMPUTED TOMOGRAPHY
ENZYME INHIBITORS
BIOLOGICAL EFFECTS
CARDIOVASCULAR DISEASES
INHALATION
PATIENTS
XENON 133
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
EMISSION COMPUTED TOMOGRAPHY
EVEN-ODD NUCLEI
INTAKE
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
NERVOUS SYSTEM
NUCLEI
ORGANS
RADIOISOTOPES
TOMOGRAPHY
XENON ISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics