Linkage analysis of IL4 and other chromosome 5q31.1 markers and total serum immunoglobulin E concentrations

Journal Article · Fri May 20 00:00:00 EDT 1994 · Science

DOI:https://doi.org/10.1126/science.8178175· OSTI ID:68726

Marsh, D G; Neely, J D; Ghosh, B; Freidhoff, L R; Ehrlich-Kautzky, E; Krishnaswamy, G ^[1]; Breazeale, D R; Beaty, T H ^[2]; Schou, C ^[3]

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1. Johns Hopkins Asthma and Allergy Center, School of Medicine, Baltimore, MD (United States)
2. Johns Hopkins School of Hygiene, Baltimore, MD (United States)
3. Allergologisk (ALK) Laboratorium A/S, Horsholm (Denmark)

Sib-pair analysis of 170 individuals from 11 Amish families revealed evidence for linkage of five markers in chromosome 5q31.1 with a gene controlling total serum immunoglobulin E (lgE) concentration. No linkage was found between these markers and specific lgE antibody concentrations. Analysis of total lgE within a subset of 128 lgE antibody-negative sib pairs confirmed evidence for linkage to 5q31.1., especially to the interleukin-4 gene (IL4). A combination of segregation and maximum likelihood analyses provided further evidence for this linkage. These analyses suggest that IL4 or a nearby gene in 5q31.1 regulates lgE production in a nonantigen-specific (noncognate) fashion. 37 refs., 2 figs., 2 tabs.

• Sponsoring Organization: USDOE
• OSTI ID: 68726
• Journal Information: Science, Vol. 264, Issue 5162; Other Information: PBD: 20 May 1994
• Country of Publication: United States
• Language: English

Related Subjects

55 BIOLOGY AND MEDICINE
BASIC STUDIES
IMMUNOGLOBULINS
GENE REGULATION
ASTHMA
GENETIC CONTROL
HUMAN CHROMOSOME 5
GENETIC MAPPING