Impairment of vitamin D metabolism due to environmental cadmium exposure, and possible relevance to sex-related differences in vulnerability to the bone damage

Journal Article · Tue Dec 01 00:00:00 EST 1992 · Journal of Toxicology and Environmental Health; (United States)

DOI:https://doi.org/10.1080/15287399209531690· OSTI ID:6833231

Tsuritani, Ikiko; Honda, Ryumon; Ishizaki, Masao; Yamada, Yuichi ^[1]; Kido, Teruhiko; Nogawa, Koji ^[2]

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1. Kanazawa Medical Univ., Ishikawa (Japan)
2. Chiba Univ. (Japan)

To determine whether depleted serum 1[alpha],25-dihydroxyvitamin D (VD) concentrations are associated with cadmium (Cd)-induced renal damage, the relationships between four indices of renal function and two indicators of bone metabolism, that is, serum VD and parathyroid hormone (PTH) concentrations, were analyzed in 30 male and 44 female subjects exposed to environmental Cd. Also, these associations were compared in male and female subjects to evaluate sex-related differences in vulnerability to the bone damage observed in Cd-exposed persons. Serum VD decreased significantly with declines in creatinine clearance and percentage tubular reabsorption of phosphate, and with increases in serum creatinine and serum [beta][sub 2]-microglobulin ([beta][sub 2]m) concentrations in the female subjects exposed to Cd, but not in the male subjects. The correlation between serum VD and PTH levels was also significant only in the females. Correlation coefficients between serum [beta][sub 2]m and VD and those between serum PTH and VD in both sexes were significantly different. These results suggest that renal damage due to Cd exposure leads to the decreases in the serum VD level and increases in serum PTH level, and that the more marked changes in serum VD and PTH in the women may play a role in the development of sex-related differences in Cd-induced bone injury.

• OSTI ID: 6833231
• Journal Information: Journal of Toxicology and Environmental Health; (United States), Vol. 37:4; ISSN 0098-4108
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
54 ENVIRONMENTAL SCIENCES
BONE TISSUES
BIOLOGICAL EFFECTS
CHRONIC EXPOSURE
CADMIUM
ENVIRONMENTAL EXPOSURE
TOXICITY
KIDNEYS
JAPAN
LAND POLLUTION
METABOLISM
SEX
SOILS
VITAMIN D
ANIMAL TISSUES
ASIA
BODY
CONNECTIVE TISSUE
DEVELOPED COUNTRIES
ELEMENTS
METALS
ORGANS
POLLUTION
TISSUES
VITAMINS
560300* - Chemicals Metabolism & Toxicology
540220 - Environment
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