Postirradiation malignant fibrous histiocytoma expressing cytokeratin. Implications for the immunodiagnosis of sarcomas

Journal Article · Fri Jul 01 00:00:00 EDT 1988 · Am. J. Surg. Pathol.; (United States)

DOI:https://doi.org/10.1097/00000478-198807000-00007· OSTI ID:6823533

Weiss, S W; Bratthauer, G L; Morris, P A

A malignant fibrous histiocytoma of the sacrum complicating the course of radiation therapy for endometrial carcinoma is presented. Although the tumor fulfilled the clinical, radiologic, and histologic criteria for a postirradiation malignant fibrous histiocytoma of bone, it also expressed cytokeratin. That this immunoreactivity reflected keratin synthesis by the tumor and not an unusual pattern of cross-reactivity with another intermediate filament such as vimentin is strongly suggested by the reproducibility of the immunoreactivity utilizing both polyclonal and monoclonal antibodies and extinction of the immunoreactivity following absorption of the primary antiserum with keratin proteins. This is the first reported instance of keratin expression by a malignant fibrous histiocytoma; it indicates that sarcomas apart from synovial sarcoma and epithelioid sarcoma may sometimes express this protein.

• Research Organization: Armed Forces Institute of Pathology, Washington, DC (USA)
• OSTI ID: 6823533
• Journal Information: Am. J. Surg. Pathol.; (United States), Vol. 12:7
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CARCINOMAS
RADIOTHERAPY
KERATIN
BIOSYNTHESIS
SIDE EFFECTS
SARCOMAS
RADIOINDUCTION
SKELETON
UTERUS
IMMUNE REACTIONS
MONOCLONAL ANTIBODIES
ANTIBODIES
BODY
DISEASES
FEMALE GENITALS
MEDICINE
NEOPLASMS
NUCLEAR MEDICINE
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RADIOLOGY
SCLEROPROTEINS
SYNTHESIS
THERAPY
560151* - Radiation Effects on Animals- Man