Tolerance of the liver to the effects of Yttrium-90 radiation
- Univ. Department of Surgery, Royal Perth Hospital (Australia)
There are no reliable data documenting the tolerance of the human liver to ionizing radiation from a continuous Yttrium-90 source. As Yttrium-90 incorporated into microspheres is being used to treat patients with liver cancer, it is imperative that the tolerance of the human liver to this form of radiation damage be determined. Four patients with metastatic liver cancer were treated with Yttrium-90 to deliver radiation doses above that considered tolerable when given by conventional external sources. Patients were monitored with serial estimations of liver function tests and between 7 and 9 months after treatment liver biopsies were performed. Histological examination of the liver biopsies confirmed only minimal changes in the normal liver parenchyma. These data indicate that the human liver may tolerate relatively large radiation doses when delivered by Yttrium-90 microspheres embedded in the liver parenchyma as a number of discrete point sources.
- OSTI ID:
- 6809074
- Journal Information:
- International Journal of Radiation Oncology, Biology and Physics; (USA), Vol. 18:3; ISSN 0360-3016
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
LIVER
NEOPLASMS
TOLERANCE
RADIOTHERAPY
BIOPSY
METASTASES
MICROSPHERES
PATIENTS
RADIATION DOSES
YTTRIUM 90
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DIGESTIVE SYSTEM
DISEASES
DOSES
GLANDS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
RADIOISOTOPES
RADIOLOGY
THERAPY
YTTRIUM ISOTOPES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
560161 - Radionuclide Effects
Kinetics
& Toxicology- Man