Effects of vasoactive stimuli on blood flow to choroid plexus

Journal Article · Mon Feb 01 00:00:00 EST 1988 · American Journal of Physiology; (USA)

OSTI ID:6808951

Faraci, F M; Mayhan, W G; Williams, J K; Heistad, D D ^[1]

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1. Univ. of Iowa College of Medicine, Iowa City (USA)

The goal of this study was to examine effects of vasoactive stimuli on blood flow to choroid plexus. The authors used microspheres to measure blood flow to choroid plexus and cerebrum in anesthetized dogs and rabbits. A critical assumption of the microsphere method is that microspheres do not pass through arteriovenous shunts. Blood flow values obtained with simultaneous injection of 15- and 50-{mu}m microspheres were similar, which suggest that shunting of 15-{mu}m microspheres was minimal. Blood flow to choroid plexus under control conditions was 287 {plus minus} 26 (means {plus minus} SE) ml {center dot} min{sup {minus}1} {center dot} 100 g{sup {minus}1} in dogs and 385 {plus minus} 73 ml {center dot} min{sup {minus}1} 100 g{sup {minus}1} in rabbits. Consecutive measurements under control conditions indicated that values for blood flow are reproducible. Adenosine did not alter blood flow to cerebrum but increased blood flow to choroid plexus two- to threefold in dogs and rabbits. Norepinephrine and phenylephrine did not affect blood flow to choroid plexus and cerebrum but decreased blood flow to choroid plexus by {approx} 50%. The authors suggest that (1) the microsphere method provides reproducible valid measurements of blood flow to the choroid plexus in dogs and rabbits and (2) vasoactive stimuli may have profoundly different effects on blood flow to choroid plexus and cerebrum.

• OSTI ID: 6808951
• Journal Information: American Journal of Physiology; (USA), Vol. 254:2; ISSN 0002-9513
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ADENOSINE
BIOLOGICAL EFFECTS
ADRENALINE
BLOOD FLOW
RADIOASSAY
CEREBRUM
CERIUM 141
DOGS
GADOLINIUM 153
MICROSPHERES
NIOBIUM 95
RABBITS
SCANDIUM 46
STRONTIUM 85
TIN 113
VASODILATORS
ADRENAL HORMONES
ALKALINE EARTH ISOTOPES
ANIMALS
AUTONOMIC NERVOUS SYSTEM AGENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
BRAIN
CARDIOTONICS
CARDIOVASCULAR AGENTS
CENTRAL NERVOUS SYSTEM
CERIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
EVEN-ODD NUCLEI
GADOLINIUM ISOTOPES
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
INTERNAL CONVERSION RADIOISOTOPES
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MAMMALS
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NEUROREGULATORS
NIOBIUM ISOTOPES
NUCLEI
NUCLEOSIDES
NUCLEOTIDES
ODD-EVEN NUCLEI
ODD-ODD NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
RARE EARTH ISOTOPES
RARE EARTH NUCLEI
RIBOSIDES
SCANDIUM ISOTOPES
SECONDS LIVING RADIOISO
STRONTIUM ISOTOPES
SYMPATHOMIMETICS
TIN ISOTOPES
VERTEBRATES
551001* - Physiological Systems- Tracer Techniques