Solubility, retention, and metabolism of intratracheally and orally administered inorganic arsenic compounds in the hamster
The absorption, biotransformation, and tissue retention of arsenic following intratracheal and oral administration of /sup 74/As-labeled sodium arsenite, sodium arsenate, arsenic trisulfide (suspension), and lead arsenate (suspension) have been studied in hamsters, and correlated to the in vitro and in vivo solubility of the compounds. After intratracheal instillation, the clearance of /sup 74/As from the lungs was positively correlated to the in vivo solubility. Less than 0.1% of the sodium arsenite and sodium arsenate was retained in the lungs after 3 days, compared to 1.3% of the arsenic trisulfide particles and 45% of the lead arsenate particles. The latter showed a very low solubility both in vivo and in vitro. In general, orally administered arsenic had a shorter biological half-life than intratracheally administered, especially when given in the form of arsenic trisulfide or lead arsenate particles, which seemed to be absorbed to only 20-30% in the gastrointestinal tract. Reduction, oxidation, and methylation of arsenic varied to a great extent with the arsenic compound and the route of exposure. Trivalent arsenic was methylated to a greater extent than pentavalent and less soluble compounds (suspended particles) more than dissolved compounds. The trivalent arsenic compounds caused higher concentrations than the pentavalent in the upper gastrointestinal tract but not in other tissues.
- Research Organization:
- CEC Joint Research Centre, Ispra, Italy
- OSTI ID:
- 6791396
- Journal Information:
- Environ. Res.; (United States), Vol. 42:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
ARSENIC COMPOUNDS
COMPARATIVE EVALUATIONS
METABOLISM
RETENTION
SOLUBILITY
ARSENIC 74
CHEMICAL STATE
HAMSTERS
INTRATRACHEAL ADMINISTRATION
LABELLED COMPOUNDS
LUNG CLEARANCE
ORAL ADMINISTRATION
TRACER TECHNIQUES
ANIMALS
ARSENIC ISOTOPES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
CLEARANCE
DAYS LIVING RADIOISOTOPES
ELECTRON CAPTURE RADIOISOTOPES
EXCRETION
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPE APPLICATIONS
ISOTOPES
MAMMALS
NUCLEI
ODD-ODD NUCLEI
RADIOISOTOPES
RODENTS
SECONDS LIVING RADIOISOTOPES
VERTEBRATES
550501* - Metabolism- Tracer Techniques