Sex differential of methylmercury toxicity in spontaneously hypertensive rats (SHR)

Journal Article · Mon Dec 01 00:00:00 EST 1986 · Bull. Environ. Contam. Toxicol.; (United States)

DOI:https://doi.org/10.1007/BF01607858· OSTI ID:6787913

Tamashiro, H; Arakaki, M; Akagi, H; Hirayama, K; Murao, K; Smolensky, M H

During a study of the effect of MeHg on blood pressure in spontaneously hypertensive rats (SHR), extensive differences between males and females in mercury toxicity were observed. The SHR model, which was developed for studying spontaneous hypertension in animals and essential hypertension in man, is used widely today for this purpose. Since the sex differences in MeHg intoxication have never been reported in SHR, it was thought the findings worthy of publication. Herein, the findings on sex differences in morbidity, mortality and blood pressure of SHR treated orally with MMC (2 mg/kg/day) for 26 consecutive days are presented.

• Research Organization: National Institute for Minamata Disease, Minamata City, Japan
• OSTI ID: 6787913
• Journal Information: Bull. Environ. Contam. Toxicol.; (United States), Vol. 37:6
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
HYPERTENSION
SEX DEPENDENCE
METHYLMERCURY
TOXICITY
BLOOD PRESSURE
RATS
WEIGHT
ANIMALS
CARDIOVASCULAR DISEASES
DISEASES
MAMMALS
MERCURY COMPOUNDS
ORGANIC COMPOUNDS
ORGANIC MERCURY COMPOUNDS
RODENTS
SYMPTOMS
VASCULAR DISEASES
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology