Effect of cadmium on prenatal development and on tissue cadmium, copper, and zinc concentrations in rats

Journal Article · Sun Feb 01 00:00:00 EST 1987 · Environ. Res.; (United States)

DOI:https://doi.org/10.1016/S0013-9351(87)80006-3· OSTI ID:6785746

Baranski, B

Administration of 60 and 180 ppm Cd in the drinking water of female rats from Day 1 to Day 20 of gestation resulted in a pronounced accumulation of Cd in all organs examined with the highest increase in the intestinal wall. The copper concentration was decreased in the liver and in the intestine of females from both groups in a dose-dependent manner and in the blood of females given Cd (180 ppm). The zinc concentration was decreased only in the kidney and the intestine of females from the higher level group. The serum glucose level, hemoglobin, and hematocrit were not affected in maternal blood, but the hematocrit was reduced in fetal blood in the 60-ppm Cd group. The fetal body weight and length were decreased in both groups though litter size was not affected. The fetal growth retardation was not concomitant with an increase of Cd concentration or with a decrease of copper and zinc concentration in fetal organs. Cd concentration was not changed in the fetal brain, liver, and kidney and increased only in the gastrointestinal tract of fetuses from the 180-ppm Cd group. The zinc concentration was decreased in fetal liver in the 180-ppm group and in brain of fetuses from the 60-ppm Cd group. The copper concentration was decreased in the gastrointestinal tract and increased in kidney of fetuses from the higher level group.

• Research Organization: Institute of Occupational Medicine, Lodz, Poland
• OSTI ID: 6785746
• Journal Information: Environ. Res.; (United States), Vol. 42:1
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
CADMIUM
MEMBRANE TRANSPORT
TOXICITY
COPPER
RATS
ONTOGENESIS
ZINC
BRAIN
DOSE-RESPONSE RELATIONSHIPS
FETAL MEMBRANES
FETUSES
GASTROINTESTINAL TRACT
GROWTH
INTESTINAL ABSORPTION
KIDNEYS
LIVER
ORAL ADMINISTRATION
ABSORPTION
ANIMALS
BODY
CENTRAL NERVOUS SYSTEM
DIGESTIVE SYSTEM
ELEMENTS
GLANDS
MAMMALS
MEMBRANES
METALS
NERVOUS SYSTEM
ORGANS
RODENTS
TRANSITION ELEMENTS
UPTAKE
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology