Delivery of antifibroblast agents as adjuncts to filtration surgery. Part I--Periocular clearance of cobalt-57 bleomycin in experimental drug delivery: pilot study in the rabbit
Antitumor and antifibroblast agents show promise as adjuncts after glaucoma filtration surgery in reducing postoperative scarring and failure. We used nuclear imaging in rabbits to investigate periocular clearance of one such agent (/sup 57/Co-bleomycin). Sub-Tenon injection was compared to other delivery techniques. Our results showed that a collagen sponge and a silastic disc implant with a microhole prolonged drug delivery when compared to sub-Tenon injection alone or injection with a viscosity enhancing agent (0.5% sodium hyaluronate). We theorize that if an antifibroblast agent can be delivered in small and sustained amounts after filtration surgery, this may prolong bleb longevity and avoid unnecessary drug toxicity.
- Research Organization:
- Arizona Health Sciences Center, Tucson
- OSTI ID:
- 6778659
- Journal Information:
- Ophthalmic Surg.; (United States), Vol. 10
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
BLEOMYCIN
CLEARANCE
SENSE ORGANS DISEASES
SURGERY
CELL DIVISION
COBALT 57
COLLAGEN
FIBROBLASTS
FILTRATION
HYALURONIC ACID
RABBITS
RADIATION SOURCE IMPLANTS
AMINES
ANIMAL CELLS
ANIMALS
ANTI-INFECTIVE AGENTS
ANTIBIOTICS
ANTIMITOTIC DRUGS
ANTINEOPLASTIC DRUGS
BETA DECAY RADIOISOTOPES
CARBOHYDRATES
COBALT ISOTOPES
CONNECTIVE TISSUE CELLS
DAYS LIVING RADIOISOTOPES
DISEASES
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
IMPLANTS
INTERMEDIATE MASS NUCLEI
ISOTOPES
MAMMALS
MEDICINE
MUCOPOLYSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
POLYSACCHARIDES
PROTEINS
RADIATION SOURCES
RADIOISOTOPES
SACCHARIDES
SCLEROPROTEINS
SEPARATION PROCESSES
SOMATIC CELLS
VERTEBRATES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)