The effect of reperfusion and hyperemia on the biodistribution of the myocardial imaging agent, Tc-99m TBI

Conference · Wed May 01 00:00:00 EDT 1985 · J. Nucl. Med.; (United States)

OSTI ID:6760174

Holman, B L; Campbell, C I; Lister-James, J; Jones, A G; Kloner, R A

The behavior of Tc-99m t-butylisonitrile (TBI) was studied in the dog at rest and under conditions of hyperemia and reperfusion. After permanent occlusion of the left anterior descending artery (LAD), the correlation between the relative myocardial concentration of Tc-99m TBI and regional myocardial blood flow (MBF) was excellent (y=0.97x-1.03 (r=0.98)). In a dog model of transient hyperemia, Tc-99m TBI underestimated MBF (53 +- 10% at 3.0 +- 0.2 times normal flow and 41 +- 10% at 6.1 +- 4 times normal flow). When Tc-99m TBI was injected 3 min before reperfusion of the LAD in dogs sacrificed 10, 30 and 60 min after reperfusion, TBI and T1-201 concentrations (as a percentage of concentration in normal tissue) were 75% and 65% at 10 min after reperfusion; 79% and 73% at 30 min; and 38% and 31% at 60 min in regions where flow was reduced to 38%, 15% and 10% of normal MBF prior to reperfusion. There was no significant reduction in the rate of reperfusion when Tc-99m TBI was injected 10 min prior to reperfusion. When TBI was injected directly into the canine LAD, washout was slow (86% of maximum at 50 min and 79% at 120 min after injection. The authors conclude that Tc-99m TBI reflects regional MBF accurately in ischemic and normal resting myocardium and underestimates MBF at high values. The rate of myocardial redistribution for Tc-99m TBI after reperfusion in the animal model is similar to that for T1-201.

• Research Organization: Harvard Medical School, Boston, MA
• OSTI ID: 6760174
• Report Number(s): CONF-850611-; TRN: 87-010696
• Journal Information: J. Nucl. Med.; (United States), Vol. 26:5; Conference: 32. annual meeting of the Society of Nuclear Medicine, Houston, TX, USA, 2 Jun 1985
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
HEART
BLOOD FLOW
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RETENTION FUNCTIONS
TISSUE DISTRIBUTION
TECHNETIUM 99
DIAGNOSTIC USES
BIOLOGICAL FUNCTIONS
DOGS
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BODY
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COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
FUNCTIONS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
MAMMALS
MUSCLES
NUCLEI
ODD-EVEN NUCLEI
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ORGANS
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TECHNETIUM ISOTOPES
THALLIUM ISOTOPES
USES
VERTEBRATES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics