Glucose tolerance, insulin release, and insulin binding to monocytes in kidney transplant recipients
In order to evaluate glucose tolerance following renal transplantation, intravenous glucose tolerance tests (IVGTT), with evaluation of hormonal responses to the intravenous glucose load and percent specific /sup 125/I-insulin binding to peripheral blood monocytes, were studied in eight clinically stable kidney transplant recipients. For comparison purposes, identical studies were done in eight control subjects and seven clinically stable hemodialysis patients. One transplant recipient was glucose intolerant, with fasting hyperglycemia, elevated HbA1C, and abnormal glucose decay constant. Impaired pancreatic insulin release appeared to be the major factor accounting for his glucose intolerance. The seven glucose-tolerant transplant recipients had significantly increased insulin release during IVGTT compared to control subjects, and significant correlations were found among insulin release, glucose decay constant, and fasting blood sugar in those patients. Insulin binding to monocytes was significantly greater in transplant recipients than control subjects due to an increase in insulin binding capacity per cell. A significant correlation was found between percent specific /sup 125/I-insulin binding and steroid dose, expressed as mg/kg body weight/day, in those patients. Thus, chronic steroid administration does not cause glucose intolerance in transplant recipients who manifest steroid-associated increases in pancreatic insulin release and cellular insulin binding capacity.
- Research Organization:
- Department of Medicine, Wayne State University, School of Medicine, Detroit, MI
- OSTI ID:
- 6758914
- Journal Information:
- Am J Kidney Dis; (United States), Vol. 1:5
- Country of Publication:
- United States
- Language:
- English
Similar Records
Endocrine function after immunosuppression of pancreatic allograft by ionizing irradiation in the primate
Functionality and antidiabetic utility of β- and L-cell containing pseudoislets
Related Subjects
62 RADIOLOGY AND NUCLEAR MEDICINE
GLUCOSE
METABOLISM
INSULIN
BIOCHEMICAL REACTION KINETICS
IODINE 125
ISOTOPE APPLICATIONS
KIDNEYS
PANCREAS
PATHOLOGY
PATIENTS
TRANSPLANTS
ALDEHYDES
BETA DECAY RADIOISOTOPES
BODY
CARBOHYDRATES
DAYS LIVING RADIOISOTOPES
DIGESTIVE SYSTEM
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HEXOSES
HORMONES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
KINETICS
MONOSACCHARIDES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
PEPTIDE HORMONES
RADIOISOTOPES
REACTION KINETICS
SACCHARIDES
550201* - Biochemistry- Tracer Techniques
551001 - Physiological Systems- Tracer Techniques
550601 - Medicine- Unsealed Radionuclides in Diagnostics