Particle-macrophage relationships during the clearance of particles from the alveolar macrophage compartment
In this study, we quantitatively characterized the distributions of particles among lavageable AM over a 30 day period after the acute intratracheal instillation of /approximately/3 mg of 1.9 ..mu..m dia. polystyrene microspheres into the lungs of rats. Information obtained for particles retained in the lavageable AM compartment and particle-AM distribution data were collectively examined using a simple, first order kinetic model for AM removal from the lung. The results of our analyses suggest that a volume load of particles in a macrophage up to at least /approximately/450 ..mu..m/sup 3/ does not inhibit the mobilization of macrophages from the alveolar compartment. Additionally, the kinetic analyses of the particle-macrophage distributions suggest that macrophages that replenish those AM that are translocated from the lung on a continual basis during alveolar clearance are not and/or do not remain particle-free in the alveoli. This latter observation can be explained by: (1) the influx of particle-bearing macrophages into the alveoli, or (2) the in situ proliferation of particle bearing AM, or (3) the release of particles by AM and the subsequent phagocytosis of the particles by newly arrived cells, or (4) a combination of these possibilities. 32 refs., 7 figs., 1 tab.
- Research Organization:
- Los Alamos National Lab., NM (USA)
- DOE Contract Number:
- W-7405-ENG-36
- OSTI ID:
- 6756146
- Report Number(s):
- LA-11428-MS; ON: DE89002262
- Resource Relation:
- Other Information: Portions of this document are illegible in microfiche products
- Country of Publication:
- United States
- Language:
- English
Similar Records
DM-CSF stimulated proliferation of rat alveolar macrophages and the effects of differing particulate burden levels in alveolar macrophages on the proliferative response
Translocation of particles to the pleural space and tracheobronchial lymph nodes following lung deposition
Related Subjects
LUNG CLEARANCE
EVALUATION
MICROSPHERES
INSTALLATION
PARTICULATES
PHAGOCYTOSIS
EXPERIMENTAL DATA
LAVAGE
LUNGS
RATS
ANIMALS
BODY
CLEARANCE
DATA
EXCRETION
INFORMATION
MAMMALS
NUMERICAL DATA
ORGANS
PARTICLES
RESPIRATORY SYSTEM
RODENTS
VERTEBRATES
551000* - Physiological Systems