Relationship between antitumor effect and metabolites of 5-fluorouracil in combination treatment with 5-fluorouracil and guanosine in ascites Sarcoma 180 tumor system

Journal Article · Thu Dec 01 00:00:00 EST 1983 · Cancer Res.; (United States)

OSTI ID:6729049

Iigo, M; Kuretani, K; Hoshi, A

The antitumor activity of (6-14C)5-fluorouracil ((6-14C)FUra) against ascites Sarcoma 180 was significantly enhanced by coadministration of guanosine, and slightly by adenosine, but not by cytidine or uridine. In advanced ascites Sarcoma 180, guanosine also enhanced the action of FUra, but adenosine, uridine, and cytidine did not. The potentiation of antitumor activity by guanosine was reversed by addition of cytidine. The antitumor activity of FUra was significantly potentiated when guanosine was administered either 0 to 15 min before or 5 min after FUra. Changes in metabolites of FUra after potentiation by guanosine were investigated. The potentiation of antitumor activity of FUra by guanosine was considered to be due to an increase in incorporation of FUra into FUra-nucleotides and RNA in the tumor cells.

• Research Organization: National Cancer Center Research Inst., Chuo-ku, Tokyo, Japan
• OSTI ID: 6729049
• Journal Information: Cancer Res.; (United States), Vol. 43:12
• Country of Publication: United States
• Language: English

Related Subjects

59 BASIC BIOLOGICAL SCIENCES
ADENOSINE
BIOCHEMICAL REACTION KINETICS
CYTIDINE
FLUOROURACILS
GUANOSINE
SARCOMAS
CHEMOTHERAPY
URIDINE
CARBON 14 COMPOUNDS
METABOLISM
METABOLITES
MICE
NUCLEOTIDES
RNA
TRACER TECHNIQUES
TUMOR CELLS
ANIMAL CELLS
ANIMALS
ANTIMETABOLITES
AROMATICS
AZAARENES
AZINES
DISEASES
DRUGS
HETEROCYCLIC COMPOUNDS
HYDROXY COMPOUNDS
ISOTOPE APPLICATIONS
KINETICS
LABELLED COMPOUNDS
MAMMALS
NEOPLASMS
NUCLEIC ACIDS
NUCLEOSIDES
ORGANIC COMPOUNDS
ORGANIC FLUORINE COMPOUNDS
ORGANIC HALOGEN COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
PURINES
PYRIMIDINES
REACTION KINETICS
RIBOSIDES
RODENTS
THERAPY
URACILS
VERTEBRATES
550201* - Biochemistry- Tracer Techniques