Radiation-induced malignant and atypical peripheral nerve sheath tumors

Journal Article · Tue Apr 01 00:00:00 EST 1980 · Ann. Neurol.; (United States)

DOI:https://doi.org/10.1002/ana.410070405· OSTI ID:6720667

Foley, K M; Woodruff, J M; Ellis, F T; Posner, J B

The reported peripheral nerve complications of therapeutic irradiation in humans include brachial and lumbar plexus fibrosis and cranial and peripheral nerve atrophy. We have encountered 9 patients with malignant (7) and atypical (2) peripheral nerve tumors occurring in an irradiated site suggesting that such tumors represent another delayed effect of radiation treatment on peripheral nerve. In all instances the radio-theray was within an acceptable radiation dosage, yet 3 patients developed local radiation-induced skin and bony abnormalities. The malignant peripheral nerve sheath tumors developed only in the radiation port. Animal studies support the clinical observation that malignant peripheral nerve sheath tumors can occur as a delayed effect of irradiation.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York, NY
• OSTI ID: 6720667
• Journal Information: Ann. Neurol.; (United States), Vol. 7:4
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE TISSUES
DELAYED RADIATION EFFECTS
NEOPLASMS
RADIOINDUCTION
NERVES
RADIOTHERAPY
SIDE EFFECTS
SKIN
METASTASES
PATIENTS
ANIMAL TISSUES
BIOLOGICAL EFFECTS
BIOLOGICAL RADIATION EFFECTS
BODY
CONNECTIVE TISSUE
DISEASES
MEDICINE
NERVOUS SYSTEM
NUCLEAR MEDICINE
ORGANS
RADIATION EFFECTS
RADIOLOGY
THERAPY
TISSUES
550603* - Medicine- External Radiation in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man