Familial melanoma associated with dominant ultraviolet radiation sensitivity
Sensitivity to ultraviolet radiation was studied in lymphoblastoid cell lines derived from 32 members of two families with histories of multiple primary melanomas in several generations. As assayed by colony formation in agar or by trypan blue exclusion following irradiation, cellular sensitivity showed a bimodal distribution. All persons with melanoma or multiple moles were in the sensitive group, while some family members exhibited responses similar to those of controls. Cells from four cases of sporadic melanoma showed normal levels of sensitivity. The data are consistent with a dominantly inherited ultraviolet light sensitivity associated with these examples of familial melanoma. Spontaneous and ultraviolet light-induced sister chromatid exchange frequencies were similar to those in control cell lines. No defect in excision repair was detected in any of the above cell lines, but the sensitive group showed postirradiation inhibition of DNA replication intermediate between controls and an excision-deficient xeroderma pigmentosum cell line.
- Research Organization:
- Queensland Institute of Medical Research, Brisbane, Australia
- OSTI ID:
- 6705988
- Journal Information:
- Cancer Res.; (United States), Vol. 42:7
- Country of Publication:
- United States
- Language:
- English
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59 BASIC BIOLOGICAL SCIENCES
CELL CULTURES
GENETIC RADIATION EFFECTS
DNA
BIOLOGICAL REPAIR
BIOASSAY
COMPARATIVE EVALUATIONS
LYMPHOCYTES
MELANOMAS
RADIOSENSITIVITY
SURVIVAL CURVES
ULTRAVIOLET RADIATION
XERODERMA PIGMENTOSUM
ANIMAL CELLS
BIOLOGICAL EFFECTS
BIOLOGICAL MATERIALS
BIOLOGICAL RADIATION EFFECTS
BIOLOGICAL RECOVERY
BLOOD
BLOOD CELLS
BODY FLUIDS
CONNECTIVE TISSUE CELLS
DISEASES
ELECTROMAGNETIC RADIATION
GENETIC EFFECTS
LEUKOCYTES
MATERIALS
NEOPLASMS
NUCLEIC ACIDS
ORGANIC COMPOUNDS
RADIATION EFFECTS
RADIATIONS
RECOVERY
REPAIR
SKIN DISEASES
SOMATIC CELLS
560121* - Radiation Effects on Cells- External Source- (-1987)
550401 - Genetics- Tracer Techniques