Final report on the reproductive toxicity of acrylamide (ACRL) (CAS No. 79-06-1) in CD-1 (trade name) swiss mice

Technical Report · Fri Jan 01 00:00:00 EST 1993

OSTI ID:6648807

Acrylamide (ACRL), known to cause reproductive toxicity, neurotoxicity, and induce dominant lethal mutations, was tested in a modified Reproductive Assessment by Continuous Breeding (RACB) Protocol in Swiss CD-1 mice. Exposure to ACRL in water at dose levels of 30 ppm (9.2 mg/kg) resulted in slight reproductive toxicity (decreased pups/litter and spermatid head counts) and increased postimplantation loss (dominant lethal effect) in the absence of demonstrable neurotoxicity for the F0 animals. F1 animals dosed with 30 ppm ACRL were more severely affected than the F0 animals exhibiting a more profound effect on fertility in the presence of slight neurotoxicity (decreased grip strength in males).

• Research Organization: Research Triangle Inst., Durham, NC (United States)
• OSTI ID: 6648807
• Report Number(s): PB-93-158285/XAB; RTI-232; CNN: N01-ES-65141
• Resource Relation: Other Information: See also PB--89-140008 and Laboratory Supplement, PB--93-158293
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
ACRYLAMIDE
TOXICITY
ANIMALS
BIOLOGY
BODY
BREEDING
CONSUMPTION RATES
DEATH
FERTILITY
FOOD
HEAD
LEADING ABSTRACT
LETHAL MUTATIONS
MALES
MICE
MORTALITY
PATHOLOGY
REPRODUCTION
WEIGHT
ABSTRACTS
AMIDES
BODY AREAS
DOCUMENT TYPES
MAMMALS
MUTATIONS
NUCLEAR FUEL CONVERSION
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RODENTS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology