Selected epidemiological observations of cell-specific leukemia mortality in the USA, 1969-1977

Conference · Mon Mar 01 00:00:00 EST 1982

OSTI ID:6643463

Selvin, S; Levin, L I; Merrill, D W; Winkelstein, W Jr

Utilizing a newly available data set which includes for the first time cell-specific leukemia mortality rates for the USA during the period 1969-1977, age and sex distributions, time trends and geographic patterns have been analyzed. Four major cell types of leukemia were considered. Acute lymphatic leukemia had a bimodal distribution with the first peak in the 5 to 9 year age group and lowest rates in age group 35 to 44 after which rates rose geometrically. Acute myeloid leukemia had only a very small childhood peak with a low in the age group 5 to 9, after which the rates also rose geometrically. For both chronic lymphatic and myeloid leukemia the rates rose geometrically after age 15. Rates among females were consistently lower for each age group. The highest sex ratio was found for chronic lymhatic leukemia and is proposed to be the result of a lag period between male and female rates. During the period under study acute lymphatic leukemia mortality in adults declined by almost 10% while acute myeloid leukemia mortality increased by almost 20%. Analysis of the geographic variation of the four major cell types revealed a geographic association between acute lymphatic and acute myeloid leukemia in children, a lack of association between childhood and adult cell types and an association of acute and chronic cell types in adults.

• Research Organization: Lawrence Berkeley Lab., CA (USA)
• DOE Contract Number: AC03-76SF00098
• OSTI ID: 6643463
• Report Number(s): LBL-14234; CONF-8206140-1; ON: DE83003986
• Resource Relation: Conference: 15. annual meeting of Society for Epidemiological Research, Cincinnati, OH, USA, 17 Jun 1982; Other Information: Portions of document are illegible
• Country of Publication: United States
• Language: English

Related Subjects

99 GENERAL AND MISCELLANEOUS//MATHEMATICS, COMPUTING, AND INFORMATION SCIENCE
59 BASIC BIOLOGICAL SCIENCES
HUMAN POPULATIONS
MORTALITY
LEUKEMIA
EPIDEMIOLOGY
AGE DEPENDENCE
GEOGRAPHICAL VARIATIONS
PATHOLOGY
SEX DEPENDENCE
USA
DISEASES
HEMIC DISEASES
NEOPLASMS
NORTH AMERICA
POPULATIONS
VARIATIONS
552000* - Public Health
550900 - Pathology