Effect of cadmium on Fe/sup +3/-transferrin formation in the rat intestinal mucosa
The effect of cadmium (Cd) on iron (Fe) metabolism has been an important subject for Cd toxicity, since anemia is usually observed in Itai-Itai patients who are exposed for long periods to Cd from the surrounding environment. It was previously accepted that Cd-induced anemia was not dependent on the route of administration. Thereafter, however, it was shown that oral Cd administration was essential for the development of anemia. Studies suggest that one of the possible sensitive sites of competition between Cd and Fe is in the gastrointestinal tract. Cd competes with Fe at one or more steps in the transport system and these metals undergo the same step(s) during their absorption. An hypothesis implies that these two metals possess a common carrier. Two Fe-binding proteins, ferritin and transferrin are well documented in the case of Fe deficiency but not in Cd exposed animals. Recently, the authors reported that the status of mucosal Fe-binding proteins in rats fed with Cd was similar to that in the Fe deficient rats. The present work was performed in an attempt to clarify the effect of in vivo and in vitro Cd on mucosal transferrin formation, which is one of two main Fe-binding proteins.
- Research Organization:
- Sapporo Medical College (Japan)
- OSTI ID:
- 6599991
- Journal Information:
- Bull. Environ. Contam. Toxicol.; (United States), Vol. 41:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
CADMIUM CHLORIDES
BIOLOGICAL EFFECTS
IRON COMPOUNDS
METABOLISM
TRANSFERRIN
BIOCHEMISTRY
ABSORPTION SPECTROSCOPY
INTESTINES
MUCOUS MEMBRANES
RATS
ANIMALS
BODY
CADMIUM COMPOUNDS
CADMIUM HALIDES
CHEMISTRY
CHLORIDES
CHLORINE COMPOUNDS
DIGESTIVE SYSTEM
GASTROINTESTINAL TRACT
GLOBULINS
GLOBULINS-BETA
HALIDES
HALOGEN COMPOUNDS
MAMMALS
MEMBRANES
METALLOPROTEINS
ORGANIC COMPOUNDS
ORGANS
PROTEINS
RODENTS
SPECTROSCOPY
TRANSITION ELEMENT COMPOUNDS
VERTEBRATES
560300* - Chemicals Metabolism & Toxicology