Developmental neurotoxicity of methylmercury: the role of microtubules
The purpose of this research was to investigate the interaction of methylmercury with microtubules as a possible mechanism for methylmercury-caused developmental neurotoxicity. Methylmercury effects on developing cerebellar cortex, an area of rapid proliferation, were examined. This model was used to test the hypothesis that microtubules of the mitotic spindle are sensitive to methylmercury in vivo as well as in cultured cells. The effect of methylmercury on non-spindle microtubules was studied in cultured cells. Cellular levels of methylmercury were determined and were used to construct a dose-response relationship. The direct effects of methylmercury on microtubule assembly in vitro were also documented. The data from these three systems have been integrated to form a hypothesis for the role of microtubules in developmental neurotoxicity caused by methylmercury. 159 references, 23 figures, 16 tables.
- Research Organization:
- Rochester Univ., NY (USA)
- DOE Contract Number:
- AC02-76EV03490
- OSTI ID:
- 6596951
- Report Number(s):
- DOE/EV/03490-2435; ON: DE84016359
- Resource Relation:
- Other Information: Portions are illegible in microfiche products. Thesis
- Country of Publication:
- United States
- Language:
- English
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560305* - Chemicals Metabolism & Toxicology- Vertebrates- (-1987)