Statistical interpretation of the overdispersed distribution of radiation-induced dicentric chromosome aberrations at high LET
The hypothesis that overdispersion of the chromosome aberration number per cell results from multiple aberrations per particle traversal is investigated in mathematical terms. At a given absorbed dose, Poisson distributions are assumed both for the number of ionizing particles traversing a cell nucleus and for the number of aberrations induced by a single particle traversal. The resulting distribution of the number of aberrations per cell is the Neyman type A distribution, a special case of the generalized Poisson distribution. This function is generally overdispersed, its relative variance 1 + lambda being determined by the expectation value lambda of aberrations per particle traversal. Data from experiments with neutrons and ..cap alpha.. particles are found to agree with this theory. The developed formalism provides a method to determine the efficiency of aberration induction per particle traversal, lambda, from the frequency distribution of aberrations.
- Research Organization:
- Univ. of Goettingen, Germany
- OSTI ID:
- 6596115
- Journal Information:
- Radiat. Res.; (United States), Vol. 85:1
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
CHROMOSOMES
BIOLOGICAL RADIATION EFFECTS
DICENTRIC CHROMOSOMES
DISTRIBUTION
RADIOINDUCTION
EFFICIENCY
STATISTICAL MODELS
ALPHA PARTICLES
AMERICIUM 241
CURIUM 242
FAST NEUTRONS
FISSION NEUTRONS
LET
PLUTONIUM 239
STATISTICS
ACTINIDE ISOTOPES
ACTINIDE NUCLEI
ALPHA DECAY RADIOISOTOPES
AMERICIUM ISOTOPES
BARYONS
BIOLOGICAL EFFECTS
CHARGED PARTICLES
CURIUM ISOTOPES
DAYS LIVING RADIOISOTOPES
ELEMENTARY PARTICLES
ENERGY TRANSFER
EVEN-EVEN NUCLEI
EVEN-ODD NUCLEI
FERMIONS
HADRONS
HEAVY NUCLEI
ISOTOPES
MATHEMATICAL MODELS
MATHEMATICS
NEUTRONS
NUCLEI
NUCLEONS
ODD-EVEN NUCLEI
PLUTONIUM ISOTOPES
RADIATION EFFECTS
RADIOISOTOPES
YEARS LIVING RADIOISOTOPES
560121* - Radiation Effects on Cells- External Source- (-1987)
550400 - Genetics