Parathyroid scans and thyroid uptake of thallium 201 of subjects in chronic hemodialysis
Patients in chronic hemodialysis were injected i.v. 1mCi each Thallium Chloride 201 (TlCl) and Technetium 99m pertechnetate (Tc99m) and imagings of the thyroid and parathyroid glands were taken after 30, 60 and 90'. Parathyroid scans were obtained by computerized subtraction of the Tc99m from the TlCl image. The percentage uptake of TlCl and Tc99m was measured at 1 and 3 hrs in normal, hemodialyzed and thyroxine treated subjects as well as in untreated and thyroxine treated mice. Thyroid tests and serum electrolytes were routinely determined. Enlarged parathyroid glands were visualized in 5 out of 6 patients on hemodialysis. TlCl uptake was greatly decreased and thyroid imagings poor in patients in renal failure. This was parallel in all cases with a high serum K/sup +/. Tc99m uptake and scans were unaffected by renal status. Administration of L-thyroxine greatly reduced the thyroidal uptake and accompanying scans after both Tc99m and TlCl in human subjects as well as in experimental animals. The authors conclude the following: a) TlCl - Tc99m subtraction scans enabled visualization of hyperplastic parathyroid glands in patients in chronic hemodialysis; b) Thyroid uptake of TlCl was inversely related to the serum K/sup +/ level; and c) Both Tc99m and TlCl thyroidal uptake were inhibited by administration of L-thyroxine, hence TSH dependent.
- Research Organization:
- Veterans Administration Medical Center, Brooklyn, NY
- OSTI ID:
- 6593319
- Report Number(s):
- CONF-840619-; TRN: 87-018941
- Journal Information:
- J. Nucl. Med.; (United States), Vol. 25:5; Conference: 31. annual meeting of the Society of Nuclear Medicine, Los Angeles, CA, USA, 5 Jun 1984
- Country of Publication:
- United States
- Language:
- English
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Related Subjects
59 BASIC BIOLOGICAL SCIENCES
PARATHYROID GLANDS
SCINTISCANNING
RADIOPHARMACEUTICALS
TISSUE DISTRIBUTION
UPTAKE
THYROID
IMAGE PROCESSING
INHIBITION
INTRAVENOUS INJECTION
TECHNETIUM 99
THALLIUM 201
THALLIUM CHLORIDES
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BODY
CHLORIDES
CHLORINE COMPOUNDS
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISTRIBUTION
DRUGS
ELECTRON CAPTURE RADIOISOTOPES
ENDOCRINE GLANDS
GLANDS
HALIDES
HALOGEN COMPOUNDS
HEAVY NUCLEI
HOURS LIVING RADIOISOTOPES
INJECTION
INTAKE
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LABELLED COMPOUNDS
NUCLEI
ODD-EVEN NUCLEI
ORGANS
PROCESSING
RADIOISOTOPE SCANNING
RADIOISOTOPES
SECONDS LIVING RADIOISOTOPES
TECHNETIUM ISOTOPES
THALLIUM COMPOUNDS
THALLIUM HALIDES
THALLIUM ISOTOPES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques