Imaging of brain tumors after administration of L-(/sup 13/N)glutamate: concise communication

Journal Article · Sun Aug 01 00:00:00 EDT 1982 · J. Nucl. Med.; (United States)

OSTI ID:6581350

Reiman, R E; Benua, R S; Gelbard, A S; Allen, J C; Vomero, J J; Laughlin, J S

Cyclotron-produced L-(/sup 13/N)glutamate was used to visualize malignant intracranial tumors in 12 pediatric patients who had evidence of recurrent disease as documented by computed transaxial tomography (TCT). Imaging was performed using a rectilinear scanner, gamma camera, or a positron-emission tomograph (PET). The results indicate that /sup 13/N is rapidly taken up by a majority of brain tumors following the administration of L-(/sup 13/N)glutamate, and that /sup 13/N uptake is correlated with breakdown of the blood-brain barrier as demonstrated by contrast TCT or pertechnetate /sup 99m/Tc studies. The feasibility of using this agent in conjunction with PET is established.

• Research Organization: Memorial Sloan-Kettering Cancer Center, New York
• OSTI ID: 6581350
• Journal Information: J. Nucl. Med.; (United States), Vol. 23:8
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
59 BASIC BIOLOGICAL SCIENCES
BRAIN
POSITRON COMPUTED TOMOGRAPHY
NEOPLASMS
DIAGNOSIS
NITROGEN 13
DIAGNOSTIC USES
TECHNETIUM 99
CARBOXYLIC ACID ESTERS
ISOMERIC NUCLEI
PATIENTS
PEDIATRICS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BETA-PLUS DECAY RADIOISOTOPES
BODY
CENTRAL NERVOUS SYSTEM
COMPUTERIZED TOMOGRAPHY
DIAGNOSTIC TECHNIQUES
DISEASES
ELECTRON CAPTURE RADIOISOTOPES
EMISSION COMPUTED TOMOGRAPHY
ESTERS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
LIGHT NUCLEI
MEDICINE
MINUTES LIVING RADIOISOTOPES
NERVOUS SYSTEM
NITROGEN ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANS
RADIOISOTOPES
TECHNETIUM ISOTOPES
TOMOGRAPHY
USES
YEARS LIVING RADIOISOTOPES
550601* - Medicine- Unsealed Radionuclides in Diagnostics
550901 - Pathology- Tracer Techniques