Recurrent villonodular synovitis of the knee. Successful treatment with /sup 90/Y
A 40-year-old woman with recurrent pigmented villonodular synovitis of the knee was treated with /sup 90/Y radiocolloid. The advantages of /sup 90/Y include effectiveness, low cost, simplicity, and low morbidity. The radiophysical properties of /sup 90/Y that make it a useful therapeutic agent are short half-life, pure beta emission and good penetration of the soft tissues. Side effects are few, predictable, and for the most part, avoidable. Radionecrosis of soft tissue, needle tract pigmentation, injection site tenderness, pyrexia, and lymphocyte chromosomal abnormalities have been reported. The indications for intra-articular radiocolloid therapy are the same as for surgical synovectomy, except that it is reserved for patients older than 35 years of age. The pathologic events following /sup 90/Y therapy in experimental animals show coagulation necrosis of the synovium, followed by an intense inflammatory reaction, leading ultimately to fibrosis. /sup 90/Y is a useful adjuvant in the treatment of recurrent pigmented villonodular synovitis.
- Research Organization:
- Department of Orthopedic Surgery, Boston City Hospital, Massachusetts
- OSTI ID:
- 6580718
- Journal Information:
- Clin. Orthop.; (United States), Vol. 169
- Country of Publication:
- United States
- Language:
- English
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63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
BONE JOINTS
BIOLOGICAL RADIATION EFFECTS
RADIOTHERAPY
SIDE EFFECTS
SKELETAL DISEASES
NECROSIS
PATIENTS
RADIOCOLLOIDS
YTTRIUM 90
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
BIOLOGICAL EFFECTS
BODY
COLLOIDS
DAYS LIVING RADIOISOTOPES
DISEASES
DISPERSIONS
HOURS LIVING RADIOISOTOPES
INTERMEDIATE MASS NUCLEI
ISOMERIC TRANSITION ISOTOPES
ISOTOPES
MEDICINE
NUCLEAR MEDICINE
NUCLEI
ODD-ODD NUCLEI
ORGANS
PATHOLOGICAL CHANGES
RADIATION EFFECTS
RADIOISOTOPES
RADIOLOGY
SKELETON
THERAPY
YTTRIUM ISOTOPES
550604* - Medicine- Unsealed Radionuclides in Therapy- (1980-)
560151 - Radiation Effects on Animals- Man