Short-term variation in labelling index as a predictor of radiotherapy response in human oral cavity carcinoma
In vitro determination of (/sup 3/H)thymidine labeling index (LI) was carried out on squamous cell carcinomas of the oral cavity from 52 patients before and during radiotherapy. Pretreatment LI values ranged from 0.01% to 50%. After administration of the first 10 Gy in five consecutive daily fractions, a decrease in LI was observed in 39 cases and an enhancement in 13 cases, with an overall median 70% decrease in the initial value. The type of variation induced by radiotherapy was not related to pretreatment LI except for tumors with a very low proliferative activity, which all showed a marked increase in LI. Pretreatment LI was not indicative of short- or long-term response to radiotherapy, whereas the variation induced on LI after 10 Gy was related to the clinical outcome.
- Research Organization:
- Istituto Nazionale per lo Studio e la Cura dei Tumori, Milano, Italy
- OSTI ID:
- 6578746
- Journal Information:
- Int. J. Radiat. Oncol., Biol. Phys.; (United States), Vol. 10:7
- Country of Publication:
- United States
- Language:
- English
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