Radionuclide diagnosis and therapy of neural crest tumors using iodine-131 metaiodobenzylguanidine

Journal Article · Sun Mar 01 00:00:00 EST 1987 · J. Nucl. Med.; (United States)

OSTI ID:6576404

Hoefnagel, C A; Voute, P A; de Kraker, J; Marcuse, H R

The successful application of (/sup 131/I)metaiodobenzylguanidine (MIBG) in diagnosis and therapy of pheochromocytoma has led to its use in other tumors which derive from the neural crest and potentially concentrate this radiopharmaceutical as well. In the present series, (/sup 131/)MIBG total-body scintigraphy was used for detection of neuroblastoma in 47 patients and 47 cases of other neural crest tumors. The method was found to be as reliable in neuroblastoma (sensitivity 95%, specificity 100%), as it is in pheochromocytoma. Although other neural crest tumors may concentrate (/sup 131/I)MIBG, this is not a consistent finding; however, it is useful to investigate which tumors do, as this may provide an alternative treatment modality for some patients. Although followup is still very short, preliminary results of therapeutic use of (/sup 131/I) MIBG in 21 patients indicate that this treatment modality may be effective in neuroblastoma and malignant pheochromocytoma.

• Research Organization: The Netherlands Cancer Institute, Amsterdam
• OSTI ID: 6576404
• Journal Information: J. Nucl. Med.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

62 RADIOLOGY AND NUCLEAR MEDICINE
BODY
SCINTISCANNING
IODINE 131
DIAGNOSTIC USES
THERAPEUTIC USES
NEOPLASMS
DIAGNOSIS
GUANIDINES
PATIENTS
BETA DECAY RADIOISOTOPES
BETA-MINUS DECAY RADIOISOTOPES
CARBONIC ACID DERIVATIVES
COUNTING TECHNIQUES
DAYS LIVING RADIOISOTOPES
DIAGNOSTIC TECHNIQUES
DISEASES
INTERMEDIATE MASS NUCLEI
IODINE ISOTOPES
ISOTOPES
NUCLEI
ODD-EVEN NUCLEI
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
RADIOISOTOPE SCANNING
RADIOISOTOPES
USES
550601* - Medicine- Unsealed Radionuclides in Diagnostics