Sensitivity of mouse Skh:HR-2 to ultraviolet radiation: melanocyte inactivation

Journal Article · Sun Mar 01 00:00:00 EST 1987 · J. Invest. Dermatol.; (United States)

DOI:https://doi.org/10.1111/1523-1747.ep12465498· OSTI ID:6571341

Warren, R; Gardner, P A; Reed, J C

The hairless mouse, Skh:HR-2, was exposed to doses of ultraviolet (UV) radiation known to induce skin pigmentation. Three parameters associated with perturbations in skin pigmentation were monitored following UV exposure. These include spectroscopy (skin darkness), histology (melanocyte density), and biochemistry (melanin). Within 90 min of UV exposure, the skin became lighter. This was associated with a reduction of quantifiable melanin and the inactivation of epidermal melanocytes.

• Research Organization: Proctor and Gamble Company, Cincinnati, OH
• OSTI ID: 6571341
• Journal Information: J. Invest. Dermatol.; (United States), Vol. 3
• Country of Publication: United States
• Language: English

Related Subjects

63 RADIATION, THERMAL, AND OTHER ENVIRON. POLLUTANT EFFECTS ON LIVING ORGS. AND BIOL. MAT.
MELANIN
INACTIVATION
SKIN
RADIOSENSITIVITY
BIOLOGICAL RADIATION EFFECTS
MICE
ULTRAVIOLET RADIATION
ANIMALS
BIOLOGICAL EFFECTS
BODY
ELECTROMAGNETIC RADIATION
HYDROXY COMPOUNDS
MAMMALS
ORGANIC COMPOUNDS
ORGANIC NITROGEN COMPOUNDS
ORGANS
PIGMENTS
RADIATION EFFECTS
RADIATIONS
RODENTS
VERTEBRATES
560162* - Radionuclide Effects
Kinetics
& Toxicology- Animals
Plants
Microorganisms
& Cells